{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:38:19Z","timestamp":1785209899435,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Eosinophilic fasciitis (EF) is a rare autoimmune disease causing progressive induration of dermal, hypodermal, and muscularis fascia. The exact pathogenesis is yet to be fully understood, and a validated therapy protocol still lacks. We here aimed to realize a clinical\u2013functional characterization of these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A total of eight patients (five males, 45\u2009years average) were treated with adjuvant high\u2010dose UVA\u20101 phototherapy (90\u2009J\/cm), after having received the standard systemic immunosuppressive protocol (oral methylprednisolone switched to methotrexate). Body lesion mapping, Localized Scleroderma Assessment Tool (LoSCAT), Dermatology Life Quality Index (DLQI), High\u2010Resolution Ultrasound (HRUS) (13\u201017MHz), and ultra HRUS (55\u201370\u2009MHz) were performed at each examination time taking specific anatomical points. Gene expression analysis at a molecular level and <jats:italic>in\u2009vitro<\/jats:italic> UVA\u20101 irradiation was realized on lesional fibroblasts primary cultures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The LoSCAT and the DLQI showed to decrease significantly starting from the last UVA\u20101 session. A significant reduction in muscularis fascia thickness (\u221250% on average) was estimated starting from 3\u2009months after the last UVA\u20101 session and maintained up to 12\u2009months follow\u2010up. Tissues was detected by HRUS. The UVA\u20101 <jats:italic>in\u2009vitro<\/jats:italic> irradiation of lesional skin sites cells appeared not to affect their viability. Molecular genes analysis revealed a significant reduction of <jats:italic>IL\u20101\u00df<\/jats:italic> and of <jats:italic>TGF\u2010\u00df<\/jats:italic> genes after phototherapy, while MMPs 1,2,9 gene expression was enhanced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Comment<\/jats:title><jats:p>These preliminary <jats:italic>in\u2009vivo<\/jats:italic> and <jats:italic>in\u2009vitro<\/jats:italic> findings suggest that UVA\u20101 phototherapy is a safe and useful adjuvant therapy able to elicit anti\u2010inflammatory effects and stimulate tissue matrix digestion and remodeling at lesional sites.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.16003","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T06:07:16Z","timestamp":1639030036000},"page":"718-726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["UVA\u20101 phototherapy as adjuvant treatment for eosinophilic fasciitis: <i>in\u2009vitro<\/i> and <i>in\u2009vivo<\/i> functional characterization"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6691-4310","authenticated-orcid":false,"given":"Linda","family":"Tognetti","sequence":"first","affiliation":[{"name":"Dermatology Unit and Skin Bank Unit Department of Clinical, Surgical and Neuro\u2010sciences University of Siena  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Marrocco","sequence":"additional","affiliation":[{"name":"Dermatology Unit and Skin Bank Unit Department of Clinical, Surgical and Neuro\u2010sciences University of Siena  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1463-0313","authenticated-orcid":false,"given":"Andrea","family":"Carraro","sequence":"additional","affiliation":[{"name":"Dermatology Unit and Skin Bank Unit Department of Clinical, Surgical and Neuro\u2010sciences University of Siena  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Conticini","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Department of Clinical, Surgical and Neuro\u2010sciences University of Siena  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Habougit","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital of Saint\u2010Etienne  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Mariotti","sequence":"additional","affiliation":[{"name":"Dermatology Unit and Skin Bank Unit Department of Clinical, Surgical and Neuro\u2010sciences University of Siena  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4009-0659","authenticated-orcid":false,"given":"Elisa","family":"Cinotti","sequence":"additional","affiliation":[{"name":"Dermatology Unit and Skin Bank Unit Department of Clinical, Surgical and Neuro\u2010sciences University of Siena  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Luc","family":"Perrot","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Saint\u2010Etienne  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7762-9312","authenticated-orcid":false,"given":"Pietro","family":"Rubegni","sequence":"additional","affiliation":[{"name":"Dermatology Unit and Skin Bank Unit Department of Clinical, Surgical and Neuro\u2010sciences University of Siena  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.019"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0269-x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.3648"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000063916"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1122-2"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1990.01670290057008"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14458"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14466"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00237"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2009.00463.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa498"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep361"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9030756"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18097"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15245"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/app10072568"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10561-016-9550-0"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/BSAM.S115187"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2008.05.002"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.7573\/dic.212529"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.07.042"},{"key":"e_1_2_5_24_1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.2340\/00015555-0417","article-title":"Eosinophilic fasciitis and combined UVA1 \u2013 retinoid \u2013 corticosteroid treatment: two case reports","volume":"88","author":"Weber HO","year":"2008","journal-title":"Acta Dermato\u2010Venereologica"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-017-0700-6"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13770"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.7.851"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07802.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev290"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1270-8"},{"key":"e_1_2_5_31_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/978-3-030-45351-0_21","volume-title":"Ultrasound technology in practical dermatology","author":"Tognetti L","year":"2020"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12442"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12454"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12431"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14135"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00747.x"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-004-0513-0"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1994.tb02982.x"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14160"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03431.x"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12947"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.16003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.16003","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.16003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T14:03:30Z","timestamp":1692885810000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.16003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,8]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/ijd.16003"],"URL":"https:\/\/doi.org\/10.1111\/ijd.16003","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,8]]},"assertion":[{"value":"2021-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}