{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:12:53Z","timestamp":1782400373622,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005190","name":"Melanoma Research Alliance","doi-asserted-by":"publisher","award":["652760"],"award-info":[{"award-number":["652760"]}],"id":[{"id":"10.13039\/100005190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K08 CA215105"],"award-info":[{"award-number":["K08 CA215105"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The assessment of the sentinel lymph node is a cornerstone of melanoma staging. However, ~80% of sentinel lymph node biopsies (SLNB) are negative and nontherapeutic, and patients are unnecessarily exposed to surgery\u2010related complications. Here, we gauged the potential of the Merlin assay to reduce SLNB\u2010associated complications. The Merlin assay uses clinicopathologic variables and tumor gene expression profiling to identify low\u2010risk patients who may forgo SLNB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We utilized the Merlin test development cohort to determine SLNB complication rates for procedures performed between 2004 and 2018 at Mayo Clinic. Complications evaluated were lymphedema, seroma, infection\/cellulitis, hematoma, and wound dehiscence. Patients who underwent a completion lymph node dissection were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 558 patients were included. The overall 90\u2010day complication rate specific to SLNB (1\u2009year for lymphedema) was 17.4%. The most common complications were seroma (9.3%), infection\/cellulitis (4.8%), and lymphedema (4.3%). All three were more common in patients with a lower extremity primary tumor location versus other locations. With Merlin test results applied, SLNB\u2010related complications would have decreased by 59%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SLNB is a safe procedure but carries a significant complication rate. Merlin testing might reduce the need for SLNB and its associated complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.16056","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T19:40:07Z","timestamp":1643658007000},"page":"848-854","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Using the Merlin assay for reducing sentinel lymph node biopsy complications in melanoma: a retrospective cohort study"],"prefix":"10.1111","volume":"61","author":[{"given":"Tina J.","family":"Hieken","sequence":"first","affiliation":[{"name":"Department of Surgery Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana B.","family":"Sadurn\u00ed","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Quattrocchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajdin","family":"Kobic","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sindhuja","family":"Sominidi\u2010Damodaran","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jvalini T.","family":"Dwarkasing","sequence":"additional","affiliation":[{"name":"SkylineDx BV  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette","family":"Meerstein\u2010Kessel","sequence":"additional","affiliation":[{"name":"SkylineDx BV  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina G.","family":"Bridges","sequence":"additional","affiliation":[{"name":"Richfield Laboratory of Dermatopathology Dermpath Diagnostics  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Meves","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Cancer stat facts: melanoma of the skin.National Cancer Institute: Surveillance Epidemiology and End Results Program.https:\/\/seer.cancer.gov\/statfacts\/html\/melan.html(accessed 21 December 2020)."},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310460"},{"key":"e_1_2_5_4_1","unstructured":"National Comprehensive Cancer Network.NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). 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