{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:46:08Z","timestamp":1784547968534,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,1,30]],"date-time":"2022-01-30T00:00:00Z","timestamp":1643500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Mixed vitiligo (MV) is the coexistence of segmental vitiligo (SV) and non\u2010segmental vitiligo (NSV). The literature on MV is sparse.<\/jats:p><\/jats:sec>Objective<\/jats:title>To assess the clinicodemographic and treatment parameters in MV and compare them with SV.<\/jats:p><\/jats:sec>Methods<\/jats:title>Clinical data of MV and SV patients enrolled in our pigmentary clinic from July 2015 to December 2019 were reviewed retrospectively and compared.<\/jats:p><\/jats:sec>Results<\/jats:title>Out of a total of 4,371 vitiligo patients, 293 (6.7%) were SV while 74 (1.69%) were MV. As compared to SV, MV had significantly lower mean age of onset of segmental component (SC) (13.33\u2009\u00b1\u20099.01 vs. 15.70\u2009\u00b1\u20098.60\u2009years, P<\/jats:italic>\u2009=\u20090.03) and significantly higher proportion of patients with more than 1% body surface involvement by SC (66.2% vs. 51.5%, P<\/jats:italic>\u2009=\u20090.03) and presence of leukotrichia in the SC (66.2% vs. 51.5%, P<\/jats:italic>\u2009=\u20090.03). Topical agents and systemic immunosuppressive agents were significantly more effective in non\u2010segmental component (NSC) as compared to SC of MV. Surgical modalities were the only effective treatment modality for SC.<\/jats:p><\/jats:sec>Limitations<\/jats:title>Retrospective design, heterogeneity of treatment regimens.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Early age of onset, larger (>1%) body surface area involvement, and leukotrichia in SV predict its progression into MV with time. Treatment response to different modalities varies significantly between SC and NSC of MV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.16090","type":"journal-article","created":{"date-parts":[[2022,1,30]],"date-time":"2022-01-30T13:39:55Z","timestamp":1643549995000},"page":"982-987","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinicodemographic features of mixed vitiligo: a case\u2013control study"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6543-4649","authenticated-orcid":false,"given":"Sheetanshu","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6323-4988","authenticated-orcid":false,"given":"Keshavamurthy","family":"Vinay","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajat","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0495-6571","authenticated-orcid":false,"given":"Vishal","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Postgraduate Institute of Medical Education and Research Chandigarh 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