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Furthermore, in adults, acne has serious consequences, including a psychological impact, low self\u2010esteem, social isolation, and depression. Over the last years, the understanding of acne pathophysiology has improved, mainly thanks to the identification of the pivotal role of the microbiota. The aim of this review was to screen the most recent scientific literature on adult acne and the newly tested treatments. Clinically, therapeutic innovations for the treatment of acne have been recently developed, including pre\/probiotics, new molecules, and innovative formulations associated, however, with fewer side effects. 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