{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:26:34Z","timestamp":1772223994067,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,4,10]],"date-time":"2022-04-10T00:00:00Z","timestamp":1649548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Moderna COVID\u201019 vaccination was approved for use in the United States in December of 2020<jats:sup>1<\/jats:sup> and since that time massive public health efforts have been made to vaccinate patients against the COVID\u201019 infection. Adverse reactions from the vaccination are well\u2010reported and include both local skin reactions, such as pain, swelling, and erythema at the injection site, as well as systemic reactions including fever, malaise, headache, muscle aches, drowsiness, nausea, and vomiting. While severe serious cutaneous adverse reactions, such as Stevens\u2013Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN), remain rare; two cases of SJS\/TEN related to COVID\u201019 vaccination have been reported. We herein review the two previously reported cases of SJS\/TEN and report the first case of SJS precipitated by the Moderna Inc., MRNA 1273 COVID\u201019 vaccination in the United States. Although we review potential adverse reactions to vaccination, the benefits of COVID\u201019 vaccination outweigh the risks based on current data. Cases should be reported to the Vaccine Adverse Event Reporting System (https:\/\/vaers.hhs.gov\/) to help public health officials recognize and track these severe but rare adverse events.<\/jats:p>","DOI":"10.1111\/ijd.16222","type":"journal-article","created":{"date-parts":[[2022,4,10]],"date-time":"2022-04-10T19:20:33Z","timestamp":1649618433000},"page":"923-929","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<scp>Stevens\u2013Johnson<\/scp> syndrome precipitated by Moderna Inc. <scp>COVID<\/scp>\u201019 vaccine: a case\u2010based review of literature comparing vaccine and drug\u2010induced <scp>Stevens\u2013Johnson<\/scp> syndrome\/toxic epidermal necrolysis"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8696-8615","authenticated-orcid":false,"given":"Jessica J.","family":"Padniewski","sequence":"first","affiliation":[{"name":"Internal Medicine Residency Program Hennepin Healthcare  Hennepin Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erick","family":"Jacobson\u2010Dunlop","sequence":"additional","affiliation":[{"name":"Twin Cities Dermatopathology  Plymouth Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Albadri","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Hennepin Healthcare  Hennepin Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Hylwa","sequence":"additional","affiliation":[{"name":"Faculty Physician, Department of Dermatology Hennepin Healthcare  Hennepin Minnesota USA"},{"name":"Assistant Professor, Department of Dermatology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,10]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Fact sheet for recipients and caregivers emergency use authorization (eua) of the moderna covid\u201019 vaccine to prevent coronavirus disease 2019 (covid\u201019) in individuals 18\u2009years of age and older.https:\/\/www.fda.gov\/media\/144638\/download#page=2a"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.03.092"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2102131"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17225"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2021.06.021"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2021.06.019"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14784"},{"issue":"1","key":"e_1_2_6_9_1","first-page":"81","article-title":"Is there an association between Stevens\u2010Johnson syndrome and vaccination? A systematic review","volume":"32","author":"Grazina I","year":"2020","journal-title":"Ann Ig"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.5070\/D3241037941"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)62605-0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200102000-00022"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454\u2010200102000\u201000022"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2014.12.009"},{"key":"e_1_2_6_15_1","unstructured":"Moderna US Inc.https:\/\/www.fda.gov\/media\/144638\/download#page=2a"},{"key":"e_1_2_6_16_1","unstructured":"U.S. Food and Drug Administrationhttps:\/\/www.fda.gov\/emergency\u2010preparedness\u2010and\u2010response\/coronavirus\u2010disease\u20102019\u2010covid\u201019\/moderna\u2010covid\u201019\u2010vaccine#additional"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1999.tb00846.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.9405"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13512"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.16222","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.16222","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.16222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T08:15:25Z","timestamp":1713168925000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.16222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,10]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/ijd.16222"],"URL":"https:\/\/doi.org\/10.1111\/ijd.16222","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,10]]},"assertion":[{"value":"2021-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}