{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:16:34Z","timestamp":1790367394579,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dermal fillers have become one of the main tools for soft tissue augmentation in the field of cosmetic dermatology. There are many types of fillers. While hyaluronic acid fillers are generally accepted as ones that fill in a space, they and other materials have been shown to have a biostimulatory effect on tissue through the process of a controlled foreign body reaction. Little research is available comparing their effects in terms of new collagen formation post administration. The goal of this review article is to evaluate the biostimulatory effects and the levels of neocollagenesis of poly\u2010l\u2010lactic acid (PLLA), calcium hydroxylapatite (CaHA), polycaprolactone (PCL), and hyaluronic acid (HA). A concise summary of the evidence is provided to assist clinicians in making informed decisions when deciding between the different types of widely available fillers.<\/jats:p>","DOI":"10.1111\/ijd.16229","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T10:30:37Z","timestamp":1651228237000},"page":"1284-1288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Evaluation of the biostimulatory effects and the level of neocollagenesis of dermal fillers: a review"],"prefix":"10.1111","volume":"61","author":[{"given":"Sasha","family":"Haddad","sequence":"first","affiliation":[{"name":"A.T. Still University School of Osteopathic Medicine  Mesa Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8223-2769","authenticated-orcid":false,"given":"Hassan","family":"Galadari","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences United Arab Emirates University  Al Ain United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anant","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Dr. DY Patil Medical College  Navi Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8646-1179","authenticated-orcid":false,"given":"Mohamad","family":"Goldust","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center, Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhail","family":"Al Salam","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences United Arab Emirates University  Al Ain United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Guida","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Surgical, Medical, Dental and Morphological Science with Interest Transplant, Oncological and Regenerative Medicine University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.2.155"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.22804"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2006.00067.x"},{"key":"e_1_2_6_5_1","volume-title":"The molecular biology of the cell. 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