{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T21:23:04Z","timestamp":1783200184776,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>F2\u2010isoprostane is one of the members of biologically active prostaglandins. It is considered a reliable marker of oxidative stress. This study aimed at investigating and studying the hypothesis of the possible role of prostaglandin F2\u2010alpha (PGF2\u03b1) in the pathogenesis of vitiligo and to know if there is a possibility of using it in therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This case\u2013control study involved 30 patients with nonsegmental vitiligo and 30 healthy sex\u2010 and age\u2010matched controls over a period of 7\u2009months. Skin biopsies were taken from lesional and nonlesional vitiliginous skin of patients and from normal skin of controls for measurement of PGF2\u03b1 in tissue by ELISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The tissue levels of PGF2\u03b1 in vitiligo patients were significantly higher in both lesional and nonlesional skin than in healthy controls (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). The tissue levels of PGF2\u03b1 in lesional skin were significantly higher than in nonlesional skin (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Based on the fact that PGF2\u03b1 is a reliable biomarker of oxidative stress, in addition to our results that revealed higher tissue levels of PGF2\u03b1 in vitiliginous skin than in healthy skin, we can conclude that PGF2\u03b1 may be incriminated in the pathogenesis of vitiligo. This finding could help in the treatment of this disease by using anti\u2010PGF2\u03b1 drugs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.16307","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T03:23:46Z","timestamp":1655781826000},"page":"1390-1396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Assessment of prostaglandin F2\u2010alpha (PGF2\u03b1) in lesional and nonlesional skin of vitiligo patients"],"prefix":"10.1111","volume":"61","author":[{"given":"Noha A.","family":"Nagui","sequence":"first","affiliation":[{"name":"Dermatology Department, Faculty of Medicine Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar A.","family":"El\u2010Tartoushy","sequence":"additional","affiliation":[{"name":"Cairo  Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila A.","family":"Rashed","sequence":"additional","affiliation":[{"name":"Medical Biochemistry and Molecular Biology Department Faculty of Medicine, Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3873-3897","authenticated-orcid":false,"given":"Maha F.","family":"Elmasry","sequence":"additional","affiliation":[{"name":"Dermatology Department, Faculty of Medicine Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.07.039"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-020-1278-7"},{"key":"e_1_2_7_4_1","first-page":"260","volume-title":"Biochemistry of Lipids, Lipoproteins and Membranes","author":"Smith WL","year":"2015"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-6980(00)00093-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13111"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10059-010-0157-1"},{"key":"e_1_2_7_8_1","first-page":"21","article-title":"Evaluation of plasma Isoprostane in patients with Oral lichen planus","volume":"17","author":"Amirchaghmaghi M","year":"2016","journal-title":"J Dent (Shiraz)"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2013.121141"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2014.140405"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-021-00879-3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2007.10.009"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.191114"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.6.677"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.12.070"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.4.407"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1712605"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00666.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20090603"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12369"},{"key":"e_1_2_7_21_1","first-page":"1087","volume-title":"Dermatology","author":"Passeron T","year":"2018"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12677"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12631"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2018.11.011"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14906"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1658860"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13648"},{"key":"e_1_2_7_28_1","unstructured":"NarangT.Bimatoprost repigments vitiligo patient skin.22nd World Congress of Dermatology; 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