{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:08:15Z","timestamp":1792548495292,"version":"4.5.0"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with hypertrophic lichen planus (HLP) and squamous cell carcinoma (SCC) diagnoses present clinicians with diagnostic and disease management challenges.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To better define the clinical and treatment outcomes of patients with concomitant diagnoses of HLP and SCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Materials<\/jats:title><jats:p>A retrospective review was performed from January 1, 2008, to July 31, 2015, at Mayo Clinic. Patients with a histologic diagnosis of HLP and SCC were included. Patient demographics, associated comorbidities, histopathologic characteristics, treatment, and outcomes were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010three patients were identified; 79% were female, and mostly the lower extremities were involved. Most of the SCCs were well\u2010differentiated and <jats:italic>in\u2009situ<\/jats:italic> with the majority treated with destruction or excision. There were no cases of local recurrence, metastasis, or disease\u2010specific death during the follow\u2010up period (mean 55.8\u2009months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with diagnoses of both HLP and SCC appear to be a distinct population that is predominantly female with lesion predilection for the lower extremities. However, regardless of treatment modality or tumor size, there were no adverse outcomes. An initial trial of more conservative treatment measures with close follow\u2010up may be reasonable with biopsy of lesions unresponsive to conventional treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.16321","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T12:47:15Z","timestamp":1656506835000},"page":"1527-1531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Concomitant hypertrophic lichen planus and squamous cell carcinoma: Clinical features and treatment outcomes"],"prefix":"10.1111","volume":"61","author":[{"given":"Munir H.","family":"Idriss","sequence":"first","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naiara","family":"Barbosa","sequence":"additional","affiliation":[{"name":"The University of New Mexico, Department of Dermatology  Albuquerque New Mexico 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