{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:19:38Z","timestamp":1792513178832,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Emergence and increase of terbinafine\u2010resistant dermatophytosis led to the identification of <jats:italic>Trichophyton mentagrophytes<\/jats:italic> internal transcriber space (ITS) genotype VIII in 2017, later renamed as <jats:italic>Trichophyton indotineae<\/jats:italic> and classified as a separate species in 2020. With its suspected origin in South Asia, this novel strain has emerged in Bahrain, Canada, Denmark, Finland, France, Germany, India, Iran, Japan, Russia, and Switzerland, with its spread attributed primarily to travel and migration. Diagnosis using routine mycology laboratory techniques is unable to distinguish <jats:italic>T. indotineae<\/jats:italic> from <jats:italic>T. mentagrophytes<\/jats:italic> and <jats:italic>T. interdigitale<\/jats:italic>; specific identification requires genomic sequencing to identify unique, specific markers. One speculated reason for this recent outbreak is the unrestricted use of topical steroid creams and antifungal agents. Patients with extensive tinea corporis and cruris due to <jats:italic>T. indotineae<\/jats:italic> present with inflammatory red plaques in multiple body sites. The majority of these infections prove to be resistant to conventional antifungals, including allylamines and azoles (itraconazole and fluconazole), thus emphasizing the need for antifungal susceptibility testing before treatment initiation and for reassessing in nonresponsive patients. Molecular studies have identified several point mutations in the <jats:italic>ERG1<\/jats:italic> (terbinafine resistance) and <jats:italic>ERG11<\/jats:italic> (azole resistance) genes, which need to be analyzed further. Use of relatively new agents, such as voriconazole and luliconazole, as well as device modalities and combination therapy, could be investigated for recalcitrant <jats:italic>T. indotineae<\/jats:italic> infections.<\/jats:p>","DOI":"10.1111\/ijd.16362","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T20:01:07Z","timestamp":1658520067000},"page":"857-861","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["The emergence of <i>Trichophyton indotineae<\/i>: Implications for clinical practice"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8664-7723","authenticated-orcid":false,"given":"Aditya K.","family":"Gupta","sequence":"first","affiliation":[{"name":"Mediprobe Research Inc.  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