{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:06:41Z","timestamp":1791324401161,"version":"4.3.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["98\u20103\u2010161\u201039829"],"award-info":[{"award-number":["98\u20103\u2010161\u201039829"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rituximab is widely used for treatment of pemphigus patients. B\u2010cell activating factor (BAFF) and a proliferation\u2010inducing ligand (APRIL) play key roles in B cell survival, maturation, and differentiation. Here, the effect of rituximab on BAFF and APRIL in patients with pemphigus vulgaris (PV) was studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty PV cases and 56 healthy individuals were recruited. Patients received rituximab for a period of 6\u2009months. The levels of BAFF and APRIL were measured in the serum samples. The frequency of CD19+ B cells was measured by flow cytometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The level of BAFF was significantly higher in the patients at the baseline level than controls (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0005). The level of BAFF was significantly higher at the 3rd month follow\u2010up compared to the baseline (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.033). There was a significant increase in the BAFF level at the 6th month follow\u2010up compared to baseline (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0134). There was no significant difference in the CD19+ B cells\/total lymphocytes ratio in the PV patients between the 3rd and 6th month follow\u2010ups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elevated BAFF in the sera could be associated with PV immunopathogenesis. Inhibition of BAFF after rituximab therapy might interfere with repopulation of B cells and confer a therapeutic approach in PV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.16363","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T06:58:51Z","timestamp":1658905131000},"page":"567-574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Elevated serum level of B\u2010cell activating factor (\n                    <scp>BAFF<\/scp>\n                    ) after rituximab therapy in pemphigus vulgaris patients suggests a possible therapeutic efficacy of B\u2010cell depletion therapies combined with\n                    <scp>anti\u2010BAFF<\/scp>\n                    agents"],"prefix":"10.1111","volume":"62","author":[{"given":"Elham","family":"Daneshvar","sequence":"first","affiliation":[{"name":"Department of Dermatology Razi Hospital, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6765-8830","authenticated-orcid":false,"given":"Soheil","family":"Tavakolpour","sequence":"additional","affiliation":[{"name":"Department of Dermatology Razi Hospital, Tehran University of Medical Sciences  Tehran Iran"},{"name":"Dana\u2010Farber Cancer Institute Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidreza","family":"Mahmoudi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Razi Hospital, Tehran University of Medical Sciences  Tehran Iran"},{"name":"Autoimmune Bullous Diseases Research Center Razi Hospital, Tehran University of Medical Sciences  Tehran 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