{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:44:03Z","timestamp":1788979443398,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Sodium\u2010glucose co\u2010transporter 2 (SGLT2) inhibitors, or gliflozins, are used as mono or combined therapy in the management of diabetes. Genital infections are the most common reported adverse effect, as a result of induced glycosuria. Cutaneous features of patients experiencing vulval symptoms while on SGLT2 inhibitor therapy have not been clearly described in published literature. We have observed a specific inflammatory vulvitis with psoriasiform features in patients taking SGLT2 inhibitors, related to candidiasis in most cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Demographic and treatment outcomes of 11 patients with characteristic inflammatory changes after starting SGLT2 inhibitors were extracted from electronic records. Ninety\u2010one percent (<jats:italic>n<\/jats:italic>\u2009=\u200910) had candidiasis, treated with fluconazole. Six (54.5%) were able to continue SGLT\u20102 inhibitors through the addition of topical treatments, but five patients had to discontinue the drug.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SGLT2 inhibitors can result in characteristic inflammatory vulvitis. Treatment with topical agents and single\u2010dose antifungals may allow patients to continue their therapy to achieve improved glycemic control. In resistant cases, discontinuation of the drug is necessary. We highlight this effect so that early treatment can be initiated to alleviate symptoms and recognition of underlying cause.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.16449","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T08:44:55Z","timestamp":1665996295000},"page":"62-65","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Gliflozin (<scp>SGLT2<\/scp> inhibitor) induced vulvitis"],"prefix":"10.1111","volume":"62","author":[{"given":"Stephen J.","family":"Mounsey","sequence":"first","affiliation":[{"name":"St. John's Institute of Dermatology Guy's and St. Thomas's NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6936-3895","authenticated-orcid":false,"given":"Ying X.","family":"Teo","sequence":"additional","affiliation":[{"name":"St. John's Institute of Dermatology Guy's and St. Thomas's NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime E.","family":"Calonje","sequence":"additional","affiliation":[{"name":"St. John's Institute of Dermatology Guy's and St. Thomas's NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona Mary","family":"Lewis","sequence":"additional","affiliation":[{"name":"St. John's Institute of Dermatology Guy's and St. Thomas's NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166125"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4670-7"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)00052-8"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12825"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2012.06.012"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.766125"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028020951928"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574886311666160405110515"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2017.10.008"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2019-000725"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2017.1343810"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2013.04.012"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2012.697053"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12912"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-1584"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.16449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.16449","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.16449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T01:31:06Z","timestamp":1692581466000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.16449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,17]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/ijd.16449"],"URL":"https:\/\/doi.org\/10.1111\/ijd.16449","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,17]]},"assertion":[{"value":"2022-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}