{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T10:53:40Z","timestamp":1781002420763,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitiligo is an autoimmune disease that courses with skin depigmentation because of the destruction of melanocytes. Vitiliginous melanocyte is prone to damage because of oxidative stress which activates cellular stress response and the release of heat shock proteins such as HSP70 promoting immune activation against the melanocyte. Variants in HSP70 genes (HSPA) might alter their expression and thus modulate vitiligo susceptibility. Therefore, we sought to evaluate the role of the 5\u2032 untranslated region HSPA1A G\/C (rs1043618) and the exonic HSPA1B A\/G (rs1061581) and HSPA1L T\/C (rs2227956) gene variants in nonsegmental vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 200 nonsegmental vitiligo patients and 208 age\/gender\u2010matched healthy subjects were genotyped for rs1043618, rs1061581, and rs2227956 variants by PCR\u2010RFLP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Variants rs1043618 and rs1061581 were not associated with vitiligo susceptibility. On the other hand, the rs2227956 C allele and TC genotype were associated with protection against vitiligo. A similar effect was observed for the GAC haplotype. Any of the aforementioned HSP70 gene variants were associated with the clinical characteristics of vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that the HSPA1L rs2227956 gene variant might influence the susceptibility to vitiligo. Being the first study of HSP70 gene variants in vitiligo, further research is encouraged to corroborate these results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.16487","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T07:25:12Z","timestamp":1667892312000},"page":"225-230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Analysis of the heat shock protein 70 (<scp>HSP70<\/scp>) genetic variants in nonsegmental vitiligo patients"],"prefix":"10.1111","volume":"62","author":[{"given":"Luis Antonio","family":"Ochoa\u2010Ram\u00edrez","sequence":"first","affiliation":[{"name":"Laboratorio de Medicina Gen\u00f3mica Hospital General de Culiac\u00e1n, Servicios de Salud Sinaloa  Culiac\u00e1n Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia Paz","family":"D\u00edaz\u2010Camacho","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Ambiente y Salud Universidad Aut\u00f3noma de Occidente  Culiac\u00e1n Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha Nohem\u00ed","family":"Mellado\u2010Corrales","sequence":"additional","affiliation":[{"name":"Maestr\u00eda en Ciencias Biom\u00e9dicas Facultad de Ciencias Qu\u00edmico Biol\u00f3gicas  Culiac\u00e1n Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor Fernando","family":"Mu\u00f1oz\u2010Estrada","sequence":"additional","affiliation":[{"name":"Depto. de Dermatolog\u00eda Centro de Investigaci\u00f3n y Docencia en Ciencias de la Salud  Culiac\u00e1n Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"R\u00edos\u2010Tostado","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina Gen\u00f3mica Hospital General de Culiac\u00e1n, Servicios de Salud Sinaloa  Culiac\u00e1n Mexico"},{"name":"Cuerpo Acad\u00e9mico Inmunogen\u00e9tica y Evoluci\u00f3n UAS\u2010CA\u2010265 Facultad de Biolog\u00eda; Universidad Aut\u00f3noma de Sinaloa  Culiac\u00e1n Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Guillermo","family":"S\u00e1nchez\u2010Zazueta","sequence":"additional","affiliation":[{"name":"Cuerpo Acad\u00e9mico Inmunogen\u00e9tica y Evoluci\u00f3n UAS\u2010CA\u2010265 Facultad de Biolog\u00eda; Universidad Aut\u00f3noma de Sinaloa  Culiac\u00e1n Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas Salvador","family":"Velarde\u2010F\u00e9lix","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina Gen\u00f3mica Hospital General de Culiac\u00e1n, Servicios de Salud Sinaloa  Culiac\u00e1n Mexico"},{"name":"Maestr\u00eda en Ciencias Biom\u00e9dicas Facultad de Ciencias Qu\u00edmico Biol\u00f3gicas  Culiac\u00e1n Mexico"},{"name":"Cuerpo Acad\u00e9mico Inmunogen\u00e9tica y Evoluci\u00f3n UAS\u2010CA\u2010265 Facultad de Biolog\u00eda; Universidad Aut\u00f3noma de Sinaloa  Culiac\u00e1n Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12949"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2012.00997.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-100919-023531"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12208"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12183"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155298"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.06.186"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2014.01.004"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2015.01.006"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-8-19"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004851"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1379\/CSC-184R.1"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.4238\/2015.December.23.25"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.1.48"},{"issue":"298","key":"e_1_2_6_16_1","first-page":"302","article-title":"A fast method for high\u2010quality genomic DNA extraction from whole human blood","volume":"11","author":"Gustincich S","year":"1991","journal-title":"Biotechniques"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep24095"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.185704"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2019.05.059"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00063"},{"key":"e_1_2_6_21_1","unstructured":"The genotype\u2010tissue expression project.Single\u2010tissue eQTLs for chr6_31810495_G_A_b38. 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