{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:24:41Z","timestamp":1790699081008,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne can be considered more than a cosmetic concern due to its large impact on patients' quality of life. There are various therapeutic options for inflammatory acne, but inconvenience and undesirable side effects prompted a search for more acceptable treatments. This study aimed to compare the clinical efficacy and safety of long\u2010pulsed Nd: YAG laser 1064\u2009nm versus intralesional botulinum toxin type\u2010A (BTX\u2010A) in inflammatory acne therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective randomized split\u2010face comparative study involved 30 patients with inflammatory acne. Each patient received long\u2010pulsed Nd: YAG 1064\u2009nm laser on one side, and intralesional BTX\u2010A on the other side, monthly until improvement or maximum three sessions. Cases were assessed by acne lesions counting and grading of severity by Investigator's Global Assessment of acne (IGAs) at baseline, each session, and after 3\u2009months follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A highly statistically significant improvement in lesions count and IGAs for both sides was observed, with statistically non\u2010significant difference between both sides at end of treatment sessions. While, after 3\u2009months follow\u2010up, there was a more significant improvement at laser side.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both long\u2010pulsed Nd: YAG laser 1064\u2009nm and intralesional BTX\u2010A are safe and effective for acne therapy. Nd\u2010YAG laser has a more prolonged efficacy and lower recurrence rate than intralesional BTX\u2010A.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.16519","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T13:47:36Z","timestamp":1670248056000},"page":"822-830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["<scp>Long\u2010pulsed<\/scp> Nd: <scp>YAG<\/scp> laser (1064\u2009nm) versus intralesional botulinum toxin type (A) in acne vulgaris therapy: a split face study"],"prefix":"10.1111","volume":"62","author":[{"given":"Asia Mohammed","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Dermatology and Venereology Department Faculty of Medicine for Girls Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada Abdel Badea","family":"Omar","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology 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