{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T14:38:27Z","timestamp":1769697507259,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mastocytosis is a heterogeneous group of rare disorders characterized by the accumulation of clonal mast cells in organs such as the skin and bone marrow. The diagnosis of cutaneous mastocytosis (CM) is based on clinical findings, positive Darier's sign, and histopathology, if necessary.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of 86 children with CM diagnosed during a 35\u2010year long period were reviewed. Most patients (93%) developed CM during the first year of life (median age 3 months). Clinical features at presentation and during the follow\u2010up period were analyzed. Baseline serum tryptase level was measured in 28 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A\u00a0total\u00a0of\u00a085% of patients had maculopapular cutaneous mastocytosis\/urticaria pigmentosa (MPCM\/UP), 9% had mastocytoma, and 6% had diffuse cutaneous mastocytosis (DCM). Boy to girl ratio was 1.1:1. Fifty\u2010four\u00a0of\u00a086 patients (63%) were followed from 2 to 37\u2009years (median 13\u2009years). Complete resolution was registered in 14% of mastocytoma cases, 14% of MCPM\/UP, and in 25% of DCM patients. After the age of 18, skin lesion persisted in 14% mastocytoma, 7% MCPM\/UP, and 25% children with DCM. Atopic dermatitis was diagnosed in 9.6% of\u00a0patients with MPCM\/UP. Three\u00a0of\u00a028 patients had elevated serum tryptase. Prognosis in all patients was good, and there were no signs of progression to systemic mastocytosis (SM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To the best of our knowledge, our results represent the longest single\u2010center follow\u2010up study of childhood\u2010onset CM. We found no complications of massive mast cell degranulation or progression to SM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.16612","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T11:20:39Z","timestamp":1676892039000},"page":"616-620","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mastocytosis in children: a single\u2010center long\u2010term follow\u2010up study"],"prefix":"10.1111","volume":"62","author":[{"given":"Svetlana","family":"Popadic","sequence":"first","affiliation":[{"name":"Clinic of Dermatovenereology University Clinical Center of Serbia  Belgrade Serbia"},{"name":"University of Belgrade School of Medicine  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jovan","family":"Lalosevic","sequence":"additional","affiliation":[{"name":"Clinic of Dermatovenereology University Clinical Center of Serbia  Belgrade 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