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In co\u2010infections, the burden of an agent can be increased or decreased by the presence of others. To address this issue, we need to fully understand their prevalence, risk factors, immunology, clinical manifestations, and treatment. The purpose of this scoping review is to describe the clinical and epidemiological characteristics of the most reported viral co\u2010infections in leprosy to inform clinicians and guide future research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The authors conducted a literature search of five databases for articles on each of the aforementioned co\u2010infections published prior to October 2022. Two independent reviewers conducted the selection process and identified 53 papers meeting the study inclusion criteria. The data extraction process and evidence synthesis were conducted by one reviewer and double\u2010checked by a second one, consistent with best practice recommendations for scoping reviews.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For all assessed viruses, most studies reported prevalence rates in leprosy patients higher than the general population. Studies found that HTLV, HBV, and HCV chronic infections were highest in multibacillary leprosy, whereas HIV was mostly found in paucibacillary leprosy, and SARS\u2010Cov\u20102 affected leprosy subtypes equally. Overall, co\u2010infections were also associated with higher rates of leprosy reactions, except for COVID\u201019. Forty\u2010six percent of the studies discussed issues related to treatment, which led to favorable outcomes for the most part.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This review summarizes the existing literature on viral co\u2010infections in leprosy patients, generating valuable insights and recommending areas for future research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.16613","type":"journal-article","created":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T06:48:37Z","timestamp":1675493317000},"page":"547-557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Viral co\u2010infections in leprosy: a scoping review"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1140-3046","authenticated-orcid":false,"suffix":"Jr","given":"Luis Alberto Ribeiro","family":"Fr\u00f3es","sequence":"first","affiliation":[{"name":"Departamento de Patologia, Faculdade de Medicina Universidade de S\u00e3o Paulo Av Dr Arnaldo, 455 S\u00e3o Paulo 01246\u2010903 SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tereza Setsuko","family":"Toma","sequence":"additional","affiliation":[{"name":"N\u00facleo de Evid\u00eancias, Instituto de Sa\u00fade Secretaria de Estado da Sa\u00fade S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosana Evangelista","family":"Poderoso","sequence":"additional","affiliation":[{"name":"Biblioteca da Faculdade de Ci\u00eancias M\u00e9dicas Universidade de Campinas Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria \u00c2ngela Bianconcini","family":"Trindade","sequence":"additional","affiliation":[{"name":"LIM56, Hospital das Cl\u00ednicas, Faculdade de Medicina Universidade de S\u00e3o Paulo S\u00e3o Paulo SP Brazil"},{"name":"N\u00facleo de Evid\u00eancias, Instituto de Sa\u00fade Secretaria de Estado da Sa\u00fade S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2021.08.006"},{"issue":"36","key":"e_1_2_6_3_1","first-page":"429","article-title":"Global leprosy (Hansen disease) update, 2021: moving towards interruption of transmission","volume":"97","author":"WHO","year":"2022","journal-title":"Wkly Epidemiol Rec"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2012(10)05"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.10.138"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl18432"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.13-0167"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.812016"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2010.08.016"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25374"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2017.04.024"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003865"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16899"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16319"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/XEB.0000000000000277"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.11124\/JBIES\u201022\u201000123"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70493-5"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12028"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02756.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10412.x"},{"issue":"4","key":"e_1_2_6_21_1","first-page":"556","article-title":"HIV\u20101 infection as a risk factor for leprosy; 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