{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T15:27:30Z","timestamp":1772033250025,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T00:00:00Z","timestamp":1680393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Axillary extramammary Paget's disease (EMPD) is a rare condition with only a few cases reported in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective review and identified 16 cases of EMPD with axillary involvement. We summarized the clinical and histopathological characteristics, treatment, and prognosis, as well as reviewed the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the included patients, eight were male and eight were female with an average age of 63.9\u2009years at diagnosis. Eleven patients presented with unilateral axillary lesions, two patients with bilateral axillary lesions, and three patients with both axillary and genital involvement. Four male patients had a history of secondary malignancies. Axillary EMPD exerted the typical histological and immunohistochemical features of Paget's disease. All except for one patient underwent Mohs micrographic surgery with a mean final margin of 1.3\u2009cm, and the tumor was cleared 76.5% of the time with 1\u2009cm margins. None of the patients developed recurrence or metastasis after surgery at a mean follow\u2010up of 63.6\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Axillary EMPD shares similar clinicopathological features with typical EMPD. Careful clinical and pathological examinations are mandatory to detect possible associated malignancies and to make a correct diagnosis. Axillary EMPD usually has a good prognosis. Due to the complete margin assessment and better recurrence rates for EMPD in general, Mohs micrographic surgery is the treatment of choice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.16655","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T03:22:35Z","timestamp":1680492155000},"page":"933-937","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Extramammary Paget's disease involving the axilla: case series and literature review"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9451-1052","authenticated-orcid":false,"given":"Chunxia","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venerology Peking University First Hospital Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases Beijing China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis on Dermatoses Beijing China"},{"name":"NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7235-1879","authenticated-orcid":false,"given":"Yurong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology Peking University First Hospital Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases Beijing China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis on Dermatoses Beijing China"},{"name":"NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology Peking University First Hospital Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases Beijing China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis on Dermatoses Beijing China"},{"name":"NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology Peking University First Hospital Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases Beijing China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis on Dermatoses Beijing China"},{"name":"NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology Peking University First Hospital Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases Beijing China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis on Dermatoses Beijing China"},{"name":"NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.7148"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13883"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01174.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04604.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.3250"},{"issue":"1","key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1684\/ejd.2017.3140","article-title":"Patients with axillary Paget's disease should be carefully screened for other sites affected by the disease","volume":"28","author":"Fukuchi R","year":"2018","journal-title":"Eur J Dermatol"},{"issue":"6","key":"e_1_2_6_8_1","first-page":"10012","article-title":"Extramammary Paget's disease: what do we know and how do we treat?","volume":"26","author":"Adashek JJ","year":"2019","journal-title":"Can J Urol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol28040260"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27738"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2019.03.006"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-3205"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.08.030"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2019.02.002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.09.053"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2010.1161"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2010.12.010"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2019.01172"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2016.2791"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15282"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.16655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T03:07:25Z","timestamp":1702177645000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.16655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,2]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/ijd.16655"],"URL":"https:\/\/doi.org\/10.1111\/ijd.16655","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,2]]},"assertion":[{"value":"2022-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}