{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T21:41:10Z","timestamp":1726436470841},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of the study was to evaluate the clinical patterns of atrophy of the filiform papillae (FP) of the tongue and their relationship with the serum levels of iron and vitamin B<jats:sub>12<\/jats:sub> among patients with systemic diseases, in a tertiary care center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional, analytical, research study was designed. A systematic tongue examination was performed to evaluate the presence and clinical patterns of FP atrophy. We collected epidemiologic, clinical, and laboratory data. Statistical analysis included <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> test, Fisher's exact test, Kruskal\u2013Wallis test, and a logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 87 patients (83.9% females) were included [median age\u2009=\u200955 (range 20\u201389)\u2009years]. Endocrinopathy (60.9%) was the most frequent comorbidity. We found atrophy of the FP in 90.8% of the patients; the atrophy was mild in 83.5% of the cases, and severe in 16.5%. The most common atrophic patterns were as follows: <jats:italic>focalized<\/jats:italic> in 64 (73.6%) cases, \u201c<jats:italic>U<\/jats:italic>\u201d\u2010shaped pattern in 60 (69%), and <jats:italic>generalized<\/jats:italic> in 30 (34.5%). Geographic tongue and median rhomboid glossitis were observed in 12 (13.8%) and 11 (12.6%) subjects, respectively. Lower titers of serum iron were detected in cases with focal (median\u2009=\u200971 vs. 110\u2009mcg\/dl) and generalized (median\u2009=\u200955 vs. 78\u2009mcg\/dl) FP atrophy (<jats:italic>P\u2009=<\/jats:italic>\u20090.03 and <jats:italic>P\u2009=<\/jats:italic>\u20090.009, respectively), than their counterparts. The presence of symptomatology was related to the focal pattern of atrophy (<jats:italic>P\u2009=<\/jats:italic>\u20090.038).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A high frequency of filiform papillary atrophy of the tongue was observed in patients with comorbidities. Some atrophic patterns of the tongue were significantly associated with certain medical conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.16669","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T03:59:23Z","timestamp":1681185563000},"page":"915-923","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical atrophy patterns of filiform papillae of the tongue and their relationship with the serum levels of iron, vitamin B12 and folic acid in patients with systemic diseases"],"prefix":"10.1111","volume":"62","author":[{"given":"Lilly","family":"Esquivel\u2010Pedraza","sequence":"first","affiliation":[{"name":"Dermatology Department Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n \u201cSalvador Zubir\u00e1n\u201d  Mexico City Mexico"},{"name":"Research &amp; Educational Doctoral Program Universidad Centro Panamericano de Estudios Superiores  Zit\u00e1cuaro Michoac\u00e1n Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"Cicero\u2010Casarrubias","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n \u201cSalvador Zubir\u00e1n\u201d  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Fern\u00e1ndez\u2010Cuevas","sequence":"additional","affiliation":[{"name":"Oral Pathology Department Centro Dermatol\u00f3gico \u201cDr. Ladislao de la Pascua\u201d  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Ch\u00e1vez\u2010Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Nutrition Division Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n \u201cSalvador Zubir\u00e1n\u201d  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda P.","family":"Milke\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Nutrition Division Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n \u201cSalvador Zubir\u00e1n\u201d  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Dom\u00ednguez\u2010Cherit","sequence":"additional","affiliation":[{"name":"Dermatology Department Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n \u201cSalvador Zubir\u00e1n\u201d  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"M\u00e9ndez\u2010Flores","sequence":"additional","affiliation":[{"name":"Dermatology Department Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n \u201cSalvador Zubir\u00e1n\u201d  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor L.","family":"Guerrero\u2010Manzo","sequence":"additional","affiliation":[{"name":"Research &amp; 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