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Treatment for cAS remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>From 1975 to 2016, a total of 872 patients with cAS (379 secondary cAS [s\u2010cAS]\u00a0patients and 493 de novo cAS [dn\u2010cAS]) patients were identified from the Surveillance, Epidemiology, and End Results (SEER) database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Survival analyses were performed utilizing Kaplan\u2010Meier curves and Cox proportional hazards regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both the number of s\u2010cAS patients and dn\u2010cAS patients climbed steadily over 42\u2009years. There is a gradual increase in the proportion of s\u2010cAS among whole cAS patients for each interval, ranging from 0% to 51.2%.Taking into account a combination of Kaplan\u2010Meier and Cox regression methods, the survival of s\u2010cAS is similar to dn\u2010cAS. On multivariate analysis, older age, greater tumor size, primary site located at lower extremity, advanced stage, and no surgery were independent prognostic factors of decreased overall survival (OS) in both the s\u2010cAS and dn\u2010cAS groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Apparent increase in the number of s\u2010cAS patients requires\u00a0further attention. Surgery is still recommended for the treatment of both s\u2010cAS and dn\u2010cAS patients, and the requirement for treatment improvement is imperative.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.16673","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T07:44:37Z","timestamp":1681717477000},"page":"952-961","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Distinctive epidemiology and prognosis of de novo and secondary cutaneous angiosarcoma patients"],"prefix":"10.1111","volume":"62","author":[{"given":"Junsen","family":"Ye","sequence":"first","affiliation":[{"name":"The Department of Scientific Education The First People's Hospital of Jiande  Jiande Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Han","sequence":"additional","affiliation":[{"name":"Institute of Regenerative Biology and Medicine, Helmholtz Center Munich  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