{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T05:05:14Z","timestamp":1776402314383,"version":"3.51.2"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103751"],"award-info":[{"award-number":["82103751"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Biologic agents (also termed biologics) have become an important adjuvant\u2010targeted treatment option in autoimmune blistering disease. We evaluated the efficacy and safety of newly licensed biologics for the management of pemphigoid using a meta\u2010analysis. PubMed, EMBASE, Web of Science, and the Cochrane Library for studies involving pemphigoid patients treated with biological agents (rituximab, dupilumab, omalizumab, or mepolizumab) were searched. The pooled risk ratio (RR) with a 95% confidence interval (CI) was used to assess the short\u2010term efficacy, adverse event (AE), relapse, and long\u2010term survival. A total of seven studies involving 296 patients were identified. The pooled RRs for short\u2010term effectiveness, AE, relapse, and long\u2010term survival rate in patients treated with biological agents versus systemic corticosteroids were 1.37 (95% CI 0.95\u20131.97; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200982%; <jats:italic>P<\/jats:italic>\u2009=\u20090.09), 0.54 (95% CI 0.39\u20130.73; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200913%; <jats:italic>P<\/jats:italic>\u2009=\u20090.005), 1.36 (95% CI 0.95\u20131.96; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200916.8%; <jats:italic>P<\/jats:italic>\u2009=\u20090.19), and 1.08 (95% CI 0.95\u20131.21; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200948.1%; <jats:italic>P<\/jats:italic>\u2009=\u20090.53), respectively. Meta\u2010regression and subgroup analysis revealed that the RRs of efficacy were 2.10 (95% CI 1.61\u20132.75; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.00001) for rituximab and 2.07 (95% CI 1.61\u20132.67; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.00001) for sample size greater than 30. Compared with conventional therapy, biologics treatment was significantly associated with fewer adverse events (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), but no significant differences were found for efficacy and relapse (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). The findings demonstrate that a biologics\u2010containing regimen could minimize the occurrence of AEs and might display a comparable efficacy and recurrence to that of receiving systemic corticosteroids.<\/jats:p>","DOI":"10.1111\/ijd.16678","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T13:09:15Z","timestamp":1684760955000},"page":"1000-1008","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy and safety of biological agents for pemphigoid: a\u00a0systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9811-5436","authenticated-orcid":false,"given":"Zhipeng","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Dermatology, Daping Hospital Army Medical University  Chongqing 400042 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