{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T16:00:38Z","timestamp":1774627238171,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>YKL\u201040 is a 40\u2009kDa chitinase\u2010like glycoprotein that is predicted to contribute to the pathogenesis of several inflammatory and neoplastic conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess YKL\u201040 immunoexpression in different stages of mycosis fungoides (MF) to find out if YKL\u201040 is playing a possible role in disease pathophysiology and progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This work included 50 patients with different stages of MF diagnosed on the basis of clinical, histopathological, and both CD4 and CD8 immunophenotyping, in addition to 25 normal control skin. The Immune Reactive Score (IRS) of YKL\u201040 expression was determined in all specimens and statistically analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>YKL\u201040 expression reported a significant rise in MF lesions compared to control skin. Among MF specimens, the mildest expression was observed in the early patch stage followed by the plaque stage, while the strongest was in tumor stages. Positive correlations were discovered between IRS of YKL\u201040 expression in MF specimens and patients' age, disease chronicity, clinical staging, and TNMB classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>YKL\u201040 might participate in MF pathophysiology, and the highest expression is associated with advanced stages of the disease and poor outcomes. Therefore, it might be of value as a prognosticator for monitoring high\u2010risk MF patients and follow\u2010up assessment of treatment success.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.16758","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T04:45:44Z","timestamp":1688186744000},"page":"1147-1153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>YKL<\/scp>\u201040 immunoexpression as a prognosticator of mycosis fungoides"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0603-5365","authenticated-orcid":false,"given":"Yomna Mazid El\u2010Hamd","family":"Neinaa","sequence":"first","affiliation":[{"name":"Dermatology and Venereology Department, Faculty of Medicine Tanta University  Tanta Egypt"},{"name":"Dermatopathology Unite, Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadeer Tarek Ismaiel","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Dermatology Department One Day Surgeries Hospital  Nasr City Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanan Alsaeid","family":"Alshenawy","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Mahmoud","family":"Gamei","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Department, Faculty of Medicine Tanta University  Tanta 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