{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:16:55Z","timestamp":1747185415510,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic graft\u2010versus\u2010host disease is a severe complication of allogeneic stem cell and bone marrow transplantation. First\u2010line immunosuppressive agents, such as steroids, are used to prevent this disease; however, they have multiple side effects. Therefore, bath psoralen plus ultraviolet\u2010A (PUVA) is an alternative second\u2010line treatment. This study aimed to evaluate the clinical efficacy of bath PUVA for managing chronic graft\u2010versus\u2010host disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective, case\u2013control study included 14 patients with extensive cutaneous chronic graft\u2010versus\u2010host disease, resistant to systemic corticosteroid, treated with bath PUVA. Major and partial responses were defined as clinical improvements of &gt;70% and 50\u201370%, respectively. We analyzed the graft\u2010versus\u2010host disease clinical presentation and timing after allogeneic stem cell and bone marrow transplantation, bath PUVA doses, background diseases, additional treatments, and adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed eight major (three lichenoid and five sclerodermatoid) and six partial (three lichenoid and three sclerodermatoid) responses after a mean of 28 treatment sessions. After 6 to 25\u2009months, four of the eight patients with sclerodermatoid lesions and all those with lichenoid lesions experienced relapse but responded to additional treatment cycles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bath PUVA is well\u2010tolerated and effective for extensive cutaneous chronic graft\u2010versus\u2010host disease. It allows rapid tapering of adjuvant immunosuppressants; however, most patients require prolonged maintenance phototherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.16806","type":"journal-article","created":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T04:19:57Z","timestamp":1691813997000},"page":"1261-1265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bath psoralen plus ultraviolet\u2010A photochemotherapy for chronic graft\u2010versus\u2010host disease: a retrospective cohort study"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2964-7417","authenticated-orcid":false,"given":"Riad","family":"Kassem","sequence":"first","affiliation":[{"name":"Department of Dermatology Sheba Medical Center  Tel HaShomer Ramat Gan 52621 Israel"},{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv\u2010Yafo 69978 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