{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T16:49:30Z","timestamp":1756572570829},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Folliculitis keloidalis (FK) is a chronic hair disorder commonly affecting males with afro\u2010textured hair. It typically affects the nuchal area, but disease may also occur at extra\u2010nuchal sites. Few studies have investigated the histopathological aspects of preclinical FK. In addition to the histopathology of preclinical FK, this article is the first to describe the dermoscopic features of preclinical FK at extra\u2010nuchal sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This study was conducted in a tertiary dermatological clinic. Twenty\u2010eight patients with a clinical diagnosis of FK were prospectively enrolled from 2014 to 2016. Dermoscopy was used to identify features that were not evident with the naked eye (preclinical). These sites were subsequently biopsied. The clinical, dermoscopic, and histopathological features of these preclinical areas are described and correlated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most patients suffered a chronic disease course (mean: 7.6\u2009years) with 57.1% (<jats:italic>n<\/jats:italic>\u2009=\u200916) displaying extra\u2010nuchal involvement. Dermoscopy\u2010guided biopsy of preclinical lesions displayed perivascular dermatitis (82.1%), folliculocentric inflammation (46.3%), and fibrosis (64.3%). Novel dermoscopic findings were perifollicular scale, perifollicular erythema and pink\u2010white areas. The perifollicular scale was associated with fibrosis on histopathology (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This article lends further evidence for the existence of preclinical FK and describes its histological features. For the first time, it describes the dermoscopic features of preclinical FK. Dermoscopy may therefore be a useful tool to assess disease progression and treatment response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.16847","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T03:46:54Z","timestamp":1695354414000},"page":"1371-1377","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The clinicopathological spectrum of preclinical folliculitis keloidalis with correlation to its dermoscopic features: a cross\u2010sectional analytical study"],"prefix":"10.1111","volume":"62","author":[{"given":"Altaaf","family":"Parker","sequence":"first","affiliation":[{"name":"Dermatology Stellenbosch University Faculty of Medicine and Health Sciences  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masood Ahmed","family":"Parker","sequence":"additional","affiliation":[{"name":"Dermatology Stellenbosch University Faculty of Medicine and Health Sciences  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johann","family":"Schneider","sequence":"additional","affiliation":[{"name":"Anatomical Pathology University of Stellenbosch and National Health Laboratory Services  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Jordaan","sequence":"additional","affiliation":[{"name":"Dermatology Stellenbosch University Faculty of Medicine and Health Sciences  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem","family":"Visser","sequence":"additional","affiliation":[{"name":"Dermatology Stellenbosch University Faculty of Medicine and Health Sciences  Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.280701.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2008.00203.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.4.479"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2007.00123.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(03)00079-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197207000-00004"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.06.015"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70173-7"},{"issue":"2","key":"e_1_2_8_10_1","first-page":"154","article-title":"Acne keloidalis aggravated by football helmets","volume":"50","author":"Harris H","year":"1992","journal-title":"Cutis"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2008.00202.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199004000-00001"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01119.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20132129"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.02.013"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.08.019"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2009.03439.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07987.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04655.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-016-0134-5"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353529"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05558.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.7196\/SAMJ.6675"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2005.00196.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1993.tb02739.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.2165\/11537000-000000000-00000"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.16847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T06:40:18Z","timestamp":1697179218000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.16847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,21]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/ijd.16847"],"URL":"https:\/\/doi.org\/10.1111\/ijd.16847","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,21]]},"assertion":[{"value":"2023-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}