{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:52:04Z","timestamp":1789685524452,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis and psoriatic arthritis are chronic inflammatory skin and joint diseases requiring effective therapies. Although clinical studies have shown the efficacy of IL\u201023 inhibitors, real\u2010world data are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a single\u2010center retrospective Greek study enrolling patients with psoriatic arthritis and moderate\u2010to\u2010severe plaque psoriasis being treated at our multidisciplinary psoriasis outpatient clinic. Our aim was to investigate the efficacy and safety of IL\u201023 inhibitors guselkumab and risankizumab. Additionally, we sought to determine the clinical characteristics affecting treatment response. Primary endpoints were the evaluation of absolute Psoriasis Area and Severity Index (aPASI) and Disease Activity Index for Psoriatic Arthritis (DAPSA) at week 24.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010nine patients (55.9% male, 69.5% early onset) with a mean age of 51.7\u2009years were included. Twenty\u2010four patients (40.7%) had a concomitant psoriatic arthritis. Obesity was the main comorbidity (49.2%) with a mean body mass index (BMI) of 31.3\u2009kg\/m<jats:sup>2<\/jats:sup>. Additional comorbidities were hypertension (44.1%), dyslipidemia (32.2%), and diabetes (18.6%). Only eight patients (13.6%) were na\u00efve to previous systemic treatments, whereas 40 patients (67.8%) were bio\u2010experienced. A statistically significant improvement of aPASI and DAPSA was demonstrated after 4, 16, and 24\u2009weeks of treatment (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). IL23 blockers were also efficacious in difficult\u2010to\u2010treat areas. Clinical outcome was affected from previous treatment with biologics. Treatment response was the same between guselkumab and risankizumab (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This real\u2010world study confirms the efficacy and safety of guselkumab and risankizumab in psoriatic arthritis and psoriasis reported from clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.16849","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T11:54:41Z","timestamp":1695642881000},"page":"1404-1413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Real\u2010world data show high efficacy of <scp>IL23<\/scp> inhibitors guselkumab and risankizumab in psoriatic arthritis and difficult\u2010to\u2010treat areas"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8838-5309","authenticated-orcid":false,"given":"Aristeidis 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Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Theotokoglou","sequence":"additional","affiliation":[{"name":"Second Department of Dermatology and Venereology Attikon University General Hospital, School of Medicine, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0779-7641","authenticated-orcid":false,"given":"Antonios","family":"Kanelleas","sequence":"additional","affiliation":[{"name":"Second Department of Dermatology and Venereology Attikon University General Hospital, School of Medicine, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Syrmali","sequence":"additional","affiliation":[{"name":"Second Department of Dermatology and Venereology Attikon University General Hospital, School of Medicine, National and Kapodistrian University of Athens 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Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Papadavid","sequence":"additional","affiliation":[{"name":"Second Department of Dermatology and Venereology Attikon University General Hospital, School of Medicine, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.82"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32549-6"},{"key":"e_1_2_5_4_1","unstructured":"Living EuroGuiDerm Guideline for the systemic treatment of psoriasis vulgaris. 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