{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:12:15Z","timestamp":1783080735130,"version":"3.54.6"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Onychomycosis is the most common infective nail disease, and treatment includes topical and systemic antifungal medications. Recently, laser therapy has emerged as a therapeutic option for patients who are unable to take oral antifungal agents. We investigated the effectiveness and safety of a novel long\u2010pulsed 1,064\u2010nm gallium arsenide (GaAs) laser surgical device for onychomycosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This 24\u2010week single\u2010center, single\u2010blind, active\u2010controlled exploratory clinical study comparatively evaluated the long\u2010pulsed 1,064\u2010nm GaAs laser (Healer1064) with the short\u2010pulsed Nd:YAG laser surgical device in 20 participants randomly assigned to receive either test or control treatment at 4\u2010week intervals during the 12\u2010week treatment period. The rate of clinical improvement was evaluated by two independent dermatologist evaluators using the Onychomycosis Severity Index\u2010score (OSI\u2010score) and Turbidity Scale with standard photographs. Overall improvement and patient satisfaction were evaluated. Safety evaluation included pain intensity and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 44 (test: 25; control: 19) cases in 19 participants who completed treatment, the clinical improvement rate in the test and control groups was 52.00% (13\/52 cases) and 44.44% (9\/19 cases), respectively, with significantly lower pain scores in the test than the control group for every treatment visit (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and without severe adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The novel long\u2010pulsed 1,064\u2010nm GaAs laser showed greater, albeit nonsignificant, clinical improvement and was associated with less pain during treatment. Thus, the Healer1064 can provide satisfactory treatment outcomes through painless and effective improvement in onychomycosis symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.16869","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T10:04:46Z","timestamp":1697191486000},"page":"1492-1498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010pulsed 1,064\u2010nm gallium arsenide laser surgical device treatment for improving symptoms of onychomycosis: a\u00a0comparative analysis"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0248-7708","authenticated-orcid":false,"given":"Sun Young","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Dermatology Chung\u2010Ang University Gwangmyeong Hospital, Chung\u2010Ang University College of Medicine  Gwangmyeong\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0479-8174","authenticated-orcid":false,"given":"Sun Hye","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chung\u2010Ang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8016-8385","authenticated-orcid":false,"given":"Joon","family":"Seok","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chung\u2010Ang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jung","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Police Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0137-6849","authenticated-orcid":false,"given":"Kwang Ho","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chung\u2010Ang University Gwangmyeong Hospital, Chung\u2010Ang University College of Medicine  Gwangmyeong\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2320-7621","authenticated-orcid":false,"given":"Beom Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chung\u2010Ang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2007.00109.x"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Duration required for negative conversion of KOH mount in toenail onychomycosis according to the clinical factors and treatment regimens","volume":"18","author":"Paek 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