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Recent studies have placed an emphasis on certain medications in the pathophysiology of severe TEN, and our colleagues previously reported several cases of clinical improvement in TEN patients following hemodialysis. Here, we discuss the major considerations for initiating dialysis in TEN patients. By doing so, we hope to encourage others to explore this potential avenue for treating TEN, one of the most serious medical emergencies in the field of dermatology.<\/jats:p>","DOI":"10.1111\/ijd.16882","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T11:06:32Z","timestamp":1698404792000},"page":"5-9","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High\u2010risk adverse drug reactions: consideration of limited dialysis therapy for toxic epidermal necrolysis (TEN)"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7805-463X","authenticated-orcid":false,"given":"Guozhen","family":"Xie","sequence":"first","affiliation":[{"name":"Alix School of Medicine, Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1722-5970","authenticated-orcid":false,"given":"Thais","family":"Pincelli","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Jacksonville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LaTonya J.","family":"Hickson","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Mayo Clinic  Jacksonville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1752-0294","authenticated-orcid":false,"given":"Rokea","family":"el\u2010Azhary","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olayemi","family":"Sokumbi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Jacksonville FL USA"},{"name":"Department of Laboratory Medicine &amp; Pathology Mayo Clinic  Jacksonville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15287"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14530"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.5390"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102230.2010.03967.x"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411103311906"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2019.10.008"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.510"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13837"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.07.047"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12355"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13765"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2018.0501"},{"key":"e_1_2_2_14_1","unstructured":"HumphreyJH PerdueSS.Type IV hypersensitivity. 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