{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:49:29Z","timestamp":1790916569681,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hidradenitis suppurativa (HS) is an inflammatory disease of the inverse skin regions with an age peak at around 40\u2009years and an estimated prevalence of 1%. Nodules and abscesses can develop into fistules and scarring, which cause severe pain. HS is a progressive, life\u2010defining disease that leads to physical limitations, inability to work, and social isolation. There is still little data on the drivers of disease severity and burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The cross\u2010sectional study is based on the baseline data of 553 participants of the health care research project \u201cEsmAiL,\u201d which was carried out as a multicenter randomized controlled trial. It included adult HS\u2010patients presenting with at least three inflammatory lesions and at least a moderate impact on quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Disease activity increases with age. Men are more severely affected than women but feel less burdened. Obesity negatively influences disease activity and disease burden. Affected individuals have a higher level of education than the age adjusted population, but the unemployment rate is significantly higher. Disease activity significantly reduces quality of life and promotes depression and anxiety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HS is a severe and debilitating dermatosis. As a result of the well\u2010established factors involved, HS requires a multi\u2010causal approach to management, in addition to medical and surgical treatment. This must take into account all available therapeutic options, as well as patient education to reduce risk factors and pain, and psychological support. HS requires interdisciplinary and multi\u2010professional care. To prevent disease progression, a structured treatment plan is needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.16889","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T03:44:54Z","timestamp":1698983094000},"page":"188-195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Drivers of disease severity and burden of hidradenitis suppurativa: a cross\u2010sectional analysis on 553 German patients"],"prefix":"10.1111","volume":"63","author":[{"given":"Michael","family":"Schultheis","sequence":"first","affiliation":[{"name":"Department of Dermatology University Medical Center, Johannes Gutenberg University  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Grabbe","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center, Johannes Gutenberg University  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Staubach","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center, Johannes Gutenberg University  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Hennig","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center, Johannes Gutenberg University  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7240-8388","authenticated-orcid":false,"given":"Melanie","family":"Mauch","sequence":"additional","affiliation":[{"name":"German Society for Wound Healing and Wound Treatment (DGfW)  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Burckhardt","sequence":"additional","affiliation":[{"name":"German Society for Wound Healing and Wound Treatment (DGfW)  Giessen Germany"},{"name":"Baden\u2010Wuerttemberg Cooperative State University, School of Business and Health  Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gero","family":"Langer","sequence":"additional","affiliation":[{"name":"Institute for Health\u2010 and Nursing Science, Medical Faculty, Martin Luther University Halle\u2010Wittenberg  Halle Germany"},{"name":"Profile Centre of Health Sciences Halle, Medical Faculty Martin Luther University Halle\u2010Wittenberg  Halle Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Heise","sequence":"additional","affiliation":[{"name":"Institute for Health\u2010 and Nursing Science, Medical Faculty, Martin Luther University Halle\u2010Wittenberg  Halle Germany"},{"name":"Profile Centre of Health Sciences Halle, Medical Faculty Martin Luther University Halle\u2010Wittenberg  Halle Germany"},{"name":"Institute of General Practice and Family Medicine, Medical Faculty, Martin Luther University Halle\u2010Wittenberg  Halle Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Zamsheva","sequence":"additional","affiliation":[{"name":"Institute for Health\u2010 and Nursing Science, Medical Faculty, Martin Luther University Halle\u2010Wittenberg  Halle Germany"},{"name":"Profile Centre of Health Sciences Halle, Medical Faculty Martin Luther University Halle\u2010Wittenberg  Halle Germany"},{"name":"Institute of Medical Epidemiology, Biostatistics, and Informatics, Profile Area Clinical Studies &amp; 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