{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:27:17Z","timestamp":1778509637662,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573074"],"award-info":[{"award-number":["81573074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874246"],"award-info":[{"award-number":["81874246"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974480"],"award-info":[{"award-number":["81974480"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010031","name":"Postdoctoral Research Foundation of China","doi-asserted-by":"publisher","award":["2021M693560"],"award-info":[{"award-number":["2021M693560"]}],"id":[{"id":"10.13039\/501100010031","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010031","name":"Postdoctoral Research Foundation of China","doi-asserted-by":"publisher","award":["2021T140752"],"award-info":[{"award-number":["2021T140752"]}],"id":[{"id":"10.13039\/501100010031","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rosacea is a chronic inflammatory skin disease. The diagnosis is based on the symptoms and physical signs, which still lacks objective laboratory tests or imaging tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To propose and evaluate the upper eyelid network pattern in rosacea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants included patients diagnosed with rosacea, other facial erythematous skin diseases, and normal controls, all of whom underwent full\u2010face imaging utilizing the VISIA\u00ae system software. According to these images, researchers evaluated the condition of the upper eyelid vascular network, developed the grading scale and then compared the difference of distribution in the three groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The occurrence rate of upper eyelid vascular network in rosacea was significantly higher than that in other facial erythematous skin diseases (84.3 vs. 32.0%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and normal controls (84.3 vs. 28.0%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). The upper eyelid vascular network pattern was proposed (none [no clearly reticular vessels], mild [10\u201350% area of reticular vessels], moderate\u2010to\u2010severe [&gt;50% area of reticular vessels]). Moderate\u2010to\u2010severe grade was defined as well\u2010defined upper eyelid vascular network pattern, which was specific to patients with rosacea (rosacea vs. other facial erythematous skin diseases, adjusted odds ratio [aOR]\u2009=\u20095.814, 95% confidence interval [CI]: 3.899\u20138.670) (rosacea vs. heathy controls, aOR\u2009=\u200912.628, 95% CI: 8.334\u201319.112). The severity of the well\u2010defined pattern had no significant association with age, duration, and phenotypes of rosacea (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The well\u2010defined upper eyelid vascular network pattern specifically appeared in patients with rosacea, which could be a possible clue to the diagnosis of rosacea.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.16946","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T05:49:41Z","timestamp":1704865781000},"page":"337-344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical characteristics of the well\u2010defined upper eyelid vascular network pattern in patients with rosacea"],"prefix":"10.1111","volume":"63","author":[{"given":"Yiran","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Dermatology Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"Hunan key Laboratory of Aging Biology Xiangya Hospital, Central South University  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"Hunan key Laboratory of Aging Biology Xiangya Hospital, Central South University  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengping","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"Hunan key Laboratory of Aging Biology Xiangya Hospital, Central South University  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"Hunan key Laboratory of Aging Biology Xiangya Hospital, Central South University  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"Hunan key Laboratory of Aging Biology Xiangya Hospital, Central South University  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"Hunan key Laboratory of Aging Biology Xiangya Hospital, Central South University  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"Hunan key Laboratory of Aging Biology Xiangya Hospital, Central South University  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhixiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"Hunan key Laboratory of Aging Biology Xiangya Hospital, Central South University  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuchu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"Hunan key Laboratory of Aging Biology Xiangya Hospital, Central South University  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5879-2598","authenticated-orcid":false,"given":"Dan","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"Hunan key Laboratory of Aging Biology Xiangya Hospital, Central South University  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.01.077"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1506630"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16481"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15301"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.037"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16815"},{"issue":"6","key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/ddg.13139","article-title":"Pathogenesis and clinical presentation of rosacea as a key for a symptom\u2010oriented therapy","volume":"14","author":"Reinholz M","year":"2016","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2013.08.015"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2335"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2016.10.015"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231078"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-018-8717-9"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13783"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14084"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18151"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002151"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S373534"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13194"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.13917"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2021.104952"},{"key":"e_1_2_6_22_1","first-page":"23","article-title":"The anatomy and clinical significance of the collateral circulation between the internal and external carotid arteries through the ophthalmic artery","volume":"98","author":"Macchi C","year":"1993","journal-title":"Ital J Anat Embryol"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.22470"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00276-008-0323-8"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2016.1157360"},{"key":"e_1_2_6_26_1","unstructured":"DemirliR OttoP ViswanathanR PatwardhanS LarkeyJ.RBX\u00ae technology overview.2007;1:1\u20135."},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.16537.1"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2017.11.001"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13143"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2011.8"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.08.028"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2020.08.001"},{"key":"e_1_2_6_33_1","first-page":"16","article-title":"Advances in understanding and managing rosacea: part 1: connecting the dots between pathophysiological mechanisms and common clinical features of rosacea with emphasis on vascular changes and facial erythema","volume":"5","author":"Del Rosso JQ","year":"2012","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2011.6"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2011.7"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27492012000500016"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-003-0127-5"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-005-0120-2"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10090695"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.16946","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.16946","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.16946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:08:49Z","timestamp":1772960929000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.16946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,10]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/ijd.16946"],"URL":"https:\/\/doi.org\/10.1111\/ijd.16946","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,10]]},"assertion":[{"value":"2023-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}