{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:11:19Z","timestamp":1789067479470,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/objective<\/jats:title>\n                    <jats:p>Psoriasis is a chronic, inflammatory, and hyperproliferative skin disease. We have investigated the role of miR\u201021 and miR\u2010125b in the development of psoriasis and atopic eczema and their relation with the severity of the diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants included 40 psoriasis patients, 40 healthy controls, and 40 atopic eczema patients as a positive control group. In addition, analysis of mRNA expression of miR\u2010125b and miR\u201021 was carried out utilizing quantitative real\u2010time reverse transcription polymerase chain reaction (RT\u2010PCR) in serum samples and skin tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results have demonstrated that miR\u201021 was significantly overexpressed in the psoriatic and atopic eczema skin tissue and serum samples compared to controls, whereas miR\u2010125b was significantly down\u2010expressed in psoriatic and atopic eczema skin tissues and serum samples. There was a statistically significant positive correlation between the psoriasis area and severity index (PASI) score and miR\u201021 among the studied groups in both serum and tissue samples. In contrast, there was a statistically significant negative association between the miR\u2010125b and PASI score. On the other hand, there was no significant relation between the extent of body surface area (BSA), intensity, and subjective symptoms using visual analog scale (VAS) of atopic eczema disease and miRNA\u201021 and miRNA\u2010125b in both tissue and serum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, miR\u201021 gene expression was significantly increased in psoriatic and atopic eczema skin samples and serum samples, whereas miR\u2010125b was statistically lowered in psoriatic and atopic eczema patient samples. The miR\u201021 and miR\u2010125b expression level has a possible predictive value as a marker for psoriasis severity but not for atopic eczema severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.16962","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T06:48:12Z","timestamp":1703227692000},"page":"322-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["MicroRNA\u201021 and MicroRNA\u2010125b expression in skin tissue and serum as predictive biomarkers for psoriasis"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6219-3667","authenticated-orcid":false,"given":"Sara F.","family":"Saadawy","sequence":"first","affiliation":[{"name":"Medical Biochemistry Department, Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0878-7015","authenticated-orcid":false,"given":"Mohamed I.","family":"El\u2010Ghareeb","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Department, Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliaa","family":"Talaat","sequence":"additional","affiliation":[{"name":"Medical Biochemistry Department, Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Habif's clinical dermatology: a color guide to diagnosis and therapy. 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