{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:25:47Z","timestamp":1787603147140,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne vulgaris (AV) is one of the common dermatologic diseases that usually affects people during adolescence. Reports have shown that isotretinoin, the first\u2010line therapy option for moderate\u2010to\u2010severe AV, could lead to mood disturbances and suicidality. Impulsivity is the tendency to act prematurely without foresight and is a significant risk factor for suicidality. This study aimed to test the hypothesis that isotretinoin would lead to an increase in impulsivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventeen patients with AV were enrolled. The study was planned as a naturalistic 3\u2010month follow\u2010up study. Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Barratt Impulsiveness Scale (BIS), Go\/No\u2010go Task (GNG), and Balloon Analog Risk Task (BART) were administered before and after the isotretinoin treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found a significant improvement in the severity of anxiety (<jats:italic>P<\/jats:italic>\u2009=\u20090.015; <jats:italic>t<\/jats:italic>\u2009=\u20092.72) and depression symptoms (<jats:italic>P<\/jats:italic>\u2009=\u20090.08; <jats:italic>t<\/jats:italic>\u2009=\u20093.04) in AV patients at the end of 3\u2009months. Self\u2010report impulsivity characteristics with BIS stayed unchanged (<jats:italic>P<\/jats:italic>\u2009=\u20090.434; <jats:italic>t<\/jats:italic>\u2009=\u20090.80). Besides, no statistically significant difference was found in behavioral task results associated with response inhibition with GNG (<jats:italic>P<\/jats:italic>\u2009=\u20090.52; <jats:italic>t<\/jats:italic>\u2009=\u20090.65) and impulsive decision\u2010making with BART (<jats:italic>P<\/jats:italic>\u2009=\u20090.842; <jats:italic>t<\/jats:italic>\u2009=\u2009\u22120.20). However, there was a significant decrease in omission errors, with GNG suggesting improvement in attention domain (<jats:italic>P<\/jats:italic>\u2009=\u20090.020; <jats:italic>W<\/jats:italic>\u2009=\u200990.0) after the follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It has been demonstrated that isotretinoin treatment improves the severity of depression, anxiety symptoms, and attention performance in AV patients. However, there was no significant change in patients' impulsivity severity based on self\u2010reports and behavioral performances based on GNG and BART.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.16997","type":"journal-article","created":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T06:28:15Z","timestamp":1703312895000},"page":"484-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["No association between isotretinoin and impulsivity in patients with moderate\u2010to\u2010severe acne vulgaris"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7053-0494","authenticated-orcid":false,"given":"\u00c7a\u011fr\u0131","family":"\u00d6\u011f\u00fct","sequence":"first","affiliation":[{"name":"Department of Psychiatry U\u015fak University Faculty of Medicine  U\u015fak 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