{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T23:49:53Z","timestamp":1774309793557,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100016724","name":"Postgraduate Institute of Medical Education and Research, Chandigarh","doi-asserted-by":"publisher","award":["None"],"award-info":[{"award-number":["None"]}],"id":[{"id":"10.13039\/100016724","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human leukocyte antigen (HLA) allele frequencies have a known association with the pathogenesis of various autoimmune diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 31 Indian patients of acquired dermal macular hyperpigmentation (ADMH) and 60 unrelated, age\u2010and\u2010gender\u2010matched healthy controls. After history and clinical examination, 5\u2009ml of blood in EDTA vials was collected. These samples were subjected to DNA extraction and the expression of HLA A, B, C, DR, DQ\u2010A, and DQ\u2010B was studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a predominance of females with a gender ratio of 23\u2009:\u20098 and the most common phototype was Fitzpatrick type IV (83.9%). There was a significant association of HLA A*03:01 (OR: 5.8, CI: 1.7\u201317.0, <jats:italic>P<\/jats:italic> = 0.005), HLA B*07:02 (OR: 5.3, CI: 1.9\u201314.6, <jats:italic>P<\/jats:italic> = 0.003), HLA C*07:02 (OR: 4.3, CI: 1.8\u20139.6, <jats:italic>P<\/jats:italic> = 0.001), HLA DRB1*10:01 (OR: 7.6, CI: 1.7\u201338.00, <jats:italic>P<\/jats:italic> = 0.022), and HLA DRB1*15:02 (OR: 31.0, CI: 4.4\u2013341.8, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) with patients compared to controls, whereas HLA DQB*03:01 was less associated with patients compared to controls (OR: 0.2, CI: 0.0\u20130.6, <jats:italic>P<\/jats:italic> = 0.009).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with ADMH are more likely to have the HLA A*03:01, HLA B 07*02, HLA C*07:02, HLA DRB1*10:01, HLA DRB1*15:02 and less likely to have the HLA DQB*03:01 allele. Larger cohort studies may thus be conducted studying these specific alleles.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.17017","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T04:42:46Z","timestamp":1706071366000},"page":"773-779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Major histocompatibility complex (MHC) gene frequency in acquired dermal macular hyperpigmentation: a case control study"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6323-4988","authenticated-orcid":false,"given":"Keshavamurthy","family":"Vinay","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology &amp; Leprology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Kamat","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology &amp; Leprology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1791-965X","authenticated-orcid":false,"given":"Vignesh","family":"Narayan R","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology &amp; Leprology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjana W.","family":"Minz","sequence":"additional","affiliation":[{"name":"Department of Immunopathology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagdeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Immunopathology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuradha","family":"Bishnoi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology &amp; Leprology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debajyoti","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Histopathology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davinder","family":"Parsad","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology &amp; Leprology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muthu S.","family":"Kumaran","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology &amp; Leprology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,23]]},"reference":[{"issue":"1","key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.25259\/IJDVL_804_2021","article-title":"A Delphi consensus on the nomenclature and diagnosis of lichen planus pigmentosus and related entities","volume":"89","author":"Sarkar R","year":"2023","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.03.001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.131087"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15576"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13806"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920207783591690"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.25259\/IJDVL_219_2021"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5412806"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1978.tb01945.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_253_18"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.7241\/ourd.20192.4"},{"issue":"53","key":"e_1_2_6_13_1","first-page":"36","article-title":"Lichen planus pigmentosus: a study for association of thyroid dysfunction","volume":"14","author":"Karn D","year":"2016","journal-title":"Kathmandu Univ Med J (KUMJ)"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2003.01367.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14540"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.02880.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12502"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.5118"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(99)00135-4"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2016-103867"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1884"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.11138\/FNeur\/2017.32.2.083"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.72.2.184"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12536"},{"key":"e_1_2_6_25_1","volume-title":"HLA association with autoimmune diseases","author":"Cruz\u2010Tapias P","year":"2013"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.890522"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.17017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T17:38:59Z","timestamp":1716572339000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.17017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,23]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/ijd.17017"],"URL":"https:\/\/doi.org\/10.1111\/ijd.17017","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,23]]},"assertion":[{"value":"2023-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}