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For planning treatment and assessing outcomes, the Breslow micrometric measurement is critical. The tumor macroscopic dimension is not considered a prognostic parameter in cutaneous melanoma, although there are studies showing that tumor size is an independent prognostic factor for melanoma\u2010specific survival. Therefore, this study aimed to evaluate the macroscopic dimension of melanoma and other known prognostic factors (i.e., Breslow index, mitoses, regression, and ulceration) as predictors of sentinel lymph node outcome and survival outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective cross\u2010sectional study of 227 melanoma lesions subjected to sentinel lymph node biopsy at two Brazilian referral centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On univariate analysis, there was a statistically significant correlation between the largest macroscopic tumor dimension and the sentinel lymph node result (<jats:italic>P<\/jats:italic>\u2009=\u20090.001); however, on multivariate analysis considering all evaluated parameters, there was no significant difference between the sentinel lymph node result and the tumor macroscopic dimension (<jats:italic>P<\/jats:italic>\u2009=\u20090.2689). Regarding melanoma\u2010specific survival, the macroscopic dimension showed no significant correlation (<jats:italic>P<\/jats:italic>\u2009=\u20090.4632) in contrast to Breslow's dimension (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Breslow thickness was the only significant factor related to both the sentinel lymph node outcome and melanoma specific survival among the evaluated variables.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.17024","type":"journal-article","created":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T14:38:30Z","timestamp":1705156710000},"page":"765-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Macroscopic tumor dimension, sentinel lymph node outcome, and survival analysis among cutaneous melanoma"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6050-5292","authenticated-orcid":false,"given":"Marcel A.","family":"Asato","sequence":"first","affiliation":[{"name":"School of Medicine, The Federal University of Mato Grosso do Sul  Campo Grande Brazil"},{"name":"School of Medicine, S\u00e3o Paulo State University  Botucatu Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco A.","family":"Moraes\u2010Neto","sequence":"additional","affiliation":[{"name":"Amaral Carvalho Hospital  Ja\u00fa Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7598-7768","authenticated-orcid":false,"given":"Marcelo Padovani de Toledo","family":"Moraes","sequence":"additional","affiliation":[{"name":"School of Medicine, S\u00e3o Paulo State University  Botucatu Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1200-3730","authenticated-orcid":false,"given":"Juliana P.","family":"Ocanha\u2010Xavier","sequence":"additional","affiliation":[{"name":"School of Medicine, S\u00e3o Paulo State University  Botucatu Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6947-5627","authenticated-orcid":false,"given":"Mariangela Esther","family":"Alencar Marques","sequence":"additional","affiliation":[{"name":"School of Medicine, S\u00e3o Paulo State University  Botucatu Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0503-419X","authenticated-orcid":false,"given":"Jose Candido C.","family":"Xavier\u2010Junior","sequence":"additional","affiliation":[{"name":"School of Medicine, S\u00e3o Paulo State University  Botucatu Brazil"},{"name":"School of Medicine, Centro Universit\u00e1rio Unisalesiano Auxilium  Ara\u00e7atuba Brazil"},{"name":"Pathology Institute of Ara\u00e7atuba  Ara\u00e7atuba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20165122"},{"issue":"4","key":"e_1_2_6_3_1","first-page":"63","article-title":"Epidemiology of Melanoma","volume":"9","author":"Saginala K","year":"2021","journal-title":"Med Sci"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdin.2020.10.013"},{"key":"e_1_2_6_5_1","unstructured":"American Cancer Society.Cancer Facts & Figures2022.https:\/\/www.cancer.org\/content\/dam\/cancer\u2010org\/research\/cancer\u2010facts\u2010and\u2010statistics\/annual\u2010cancer\u2010facts\u2010and\u2010figures\/2022\/2022\u2010cancer\u2010facts\u2010and\u2010figures.pdf. 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