{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:16:41Z","timestamp":1773019001140,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2021\/04494\u20104"],"award-info":[{"award-number":["2021\/04494\u20104"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cutaneous squamous cell carcinoma (cSCC) is the most common skin malignancy in kidney transplant recipients (KTRs) as a result of immunosuppression. A worldwide increase in kidney transplantation justifies the determination of prognostic biomarkers by collecting detailed patient data on metastasis development. This study aims to characterize the clinical, epidemiological, and histopathological profiles of KTRs who developed metastasis of cSCC. We conducted a retrospective single\u2010center study on 18 KTRs and 21 immunocompetent patients (ICs) with metastatic cSCC, using data from 2004 to 2021. ICs were older (median age 70.5\u2009years) than KTRs (median age: 59.5\u2009years). Both groups were predominantly male with Fitzpatrick skin phototype I\/II. The primary tumor appeared around 83.5\u2009months post\u2010transplant, usually in sun\u2010exposed areas (61.1%), though some non\u2010exposed areas in ICs (23.8%) contradicted literature findings. KTRs took longer to develop metastasis (median: 11.0\u2009months) compared to ICs (median: 5.5\u2009months). The mean size of the primary tumor was smaller in KTRs (2.50\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    ) compared to ICs (4.55\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    ). The main lymph node chain affected by metastasis was\u00a0parotid lymph nodes in KTRs (27.8%) and cervical\/axillar lymph nodes in ICs (both 19.0%). Both groups exhibited similar primary tumor grades and metastasis evolution, but KTRs had a higher prevalence of lymphovascular invasion. Metastasis of cSCC was more common in males with low skin phototype, in KTRs, particularly on the head and neck. The study suggests a possible link between lymphovascular invasion and metastasis development in KTRs.\n                  <\/jats:p>","DOI":"10.1111\/ijd.17029","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T01:25:25Z","timestamp":1706059525000},"page":"560-564","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metastasis of skin squamous cell carcinoma in kidney transplant recipients"],"prefix":"10.1111","volume":"63","author":[{"given":"Felipe F. C.","family":"Alves","sequence":"first","affiliation":[{"name":"Medical School Student  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2347-5554","authenticated-orcid":false,"given":"Laura C. B.","family":"de Jesus","sequence":"additional","affiliation":[{"name":"Department of Medicine Post Graduate Program in Translational Medicine  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina P.","family":"Cristelli","sequence":"additional","affiliation":[{"name":"Hospital do Rim e Hipertens\u00e3o  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milvia M. 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