{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:31:48Z","timestamp":1780443108139,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100017529","name":"Major Scientific and Technological Project of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017529","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","award":["GZY\u2010ZJ\u2010KJ\u20102023035"],"award-info":[{"award-number":["GZY\u2010ZJ\u2010KJ\u20102023035"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n While observational studies have suggested a link between gut microbiota diversity and alopecia areata (AA), the causal relationship remains unclear.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We leveraged data from the MiBioGen and FinnGen consortiums' Genome\u2010wide association studies (GWAS) encompassing gut microbiota (\n n<\/jats:italic>\n \u2009=\u200913,266) and AA (\n n<\/jats:italic>\n \u2009=\u2009211,428) datasets. A comprehensive Mendelian randomization (MR) and reverse MR approach were employed, utilizing five statistical methods to evaluate causality. Sensitivity analyses were also conducted to corroborate the MR results.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Inverse variance weighted (IVW) analysis indicated a protective effect against AA from\n Butyricimonas<\/jats:italic>\n (OR\u2009=\u20090.37, 95% CI: 0.18\u20130.77,\n P<\/jats:italic>\n \u2009=\u20090.01),\n Enterorhabdus<\/jats:italic>\n (OR\u2009=\u20090.40, 95% CI: 0.16\u20130.95,\n P<\/jats:italic>\n \u2009=\u20090.04),\n Eubacterium (xylanophilum group)<\/jats:italic>\n (OR\u2009=\u20090.36, 95% CI: 0.15\u20130.84,\n P<\/jats:italic>\n \u2009=\u20090.02), and\n Phascolarctobacterium<\/jats:italic>\n (OR\u2009=\u20090.37, 95% CI: 0.15\u20130.91,\n P<\/jats:italic>\n \u2009=\u20090.03), while\n Ruminococcaceae UCG003<\/jats:italic>\n posed as a risk factor (OR\u2009=\u20092.79, 95% CI: 1.27\u20136.14,\n P<\/jats:italic>\n \u2009=\u20090.01). Reverse MR showed no significant causal link between AA and gut microbiota, with no significant heterogeneity or horizontal pleiotropy.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Our analysis suggests probable causality between certain gut microbiota and AA, shedding light on its pathogenesis and potential intervention strategies.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ijd.17032","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T07:44:57Z","timestamp":1705650297000},"page":"597-603","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Exploring the link between gut microbiota and alopecia areata: a two\u2010sample Mendelian randomization analysis"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2055-9376","authenticated-orcid":false,"given":"Wen","family":"Xu","sequence":"first","affiliation":[{"name":"School of Medicine, Zhejiang University Hangzhou People's Republic of China"},{"name":"Department of Dermatology Hangzhou Third People's Hospital, Affiliated Hangzhou Dermatology Hospital, Zhejiang University School of Medicine, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hangzhou Third People's Hospital, Affiliated Hangzhou Dermatology Hospital, Zhejiang University School of Medicine, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University Hangzhou People's Republic of China"},{"name":"Graduate School, Zhejiang Chinese Medical University Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuzu","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hangzhou Third People's Hospital, Affiliated Hangzhou Dermatology Hospital, Zhejiang University School of Medicine, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.08.032"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-021-08883-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.06.019"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.21245"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.14309\/crj.2017.107"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2021.04.003"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15885"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016010098"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00968-y"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0350-x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-00763-1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02657-x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05473-8"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3493"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03407-6"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac193"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.05.017"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.108191"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12015"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.921546"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13193286"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30712-x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO03308E"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350933"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz030"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyac041"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15880"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01961-8"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2023.08.003"}],"container-title":["International 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