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As a result of the high rate of resistance which urged for drug repurposing, statins were studied and found to have multiple pleiotropic effects, especially when combined with other already\u2010existing drugs. An example of this is the synergism found between several typical antifungals and statins, such as antifungals Imidazole and Triazole with a wide range of statins shown in this review. The main mechanisms in which they exert an antifungal effect are ergosterol inhibition, protein prenylation, mitochondrial disruption, and morphogenesis\/mating inhibition. This article discusses multiple <jats:italic>in vitro<\/jats:italic> studies that have proven the antifungal effect of systemic statins against many fungal species, whether used alone or in combination with other typical antifungals. However, as a result of the high rate of drug\u2013drug interactions and the well\u2010known side effects of systemic statins, topical statins have become of increasing interest. Furthermore, patients with dyslipidemia treated with systemic statins who have a new topical fungal infection could benefit from the antifungal effect of their statin. However, it is still not indicated to initiate systemic statins in patients with topical mycotic infections if they do not have another indication for statin use, which raises the interest in using topical statins for fungal infections. This article also tackles the different formulations that have been studied to enhance topical statins' efficacy, as well as the effect of different topical statins on distinct dermatologic fungal diseases.<\/jats:p>","DOI":"10.1111\/ijd.17068","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T09:58:39Z","timestamp":1707731919000},"page":"747-753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Topical statins as antifungals: a review"],"prefix":"10.1111","volume":"63","author":[{"given":"Dana M.","family":"Khoury","sequence":"first","affiliation":[{"name":"Department of Dermatology American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nohra","family":"Ghaoui","sequence":"additional","affiliation":[{"name":"Department of Dermatology American University of Beirut Medical Center  Beirut 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