{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:20:58Z","timestamp":1791876058009,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A filler composed of calcium hydroxylapatite and carboxymethylcellulose gel (CaHA\/CMC) has been shown to possess biostimulatory and skin\u2010tightening properties that have been applied not just to the face but also to the body to boost rejuvenation. Recently, evidence and recommendations for CaHA\/CMC treatment of the face have been provided, but they are still lacking in terms of body treatment. This article aims to perform a systematic review of the literature on CaHA\/CMC applications on the body and provide evidence from the literature. Currently, the only FDA\u2010approved indication on the body is treating the hands and a recent European Union Medical Device Regulation approval has been released for decolletage treatment. The application of hyperdilutions on the neck, feet, arms, thighs, abdomen, and other body parts has been proven to provide a skin\u2010tightening effect. However, despite their wide use with a good safety profile in clinical practice, recent trends and guidelines of diluted and hyperdiluted CaHA\/CMC have yet to be supported by randomized controlled trials.<\/jats:p>","DOI":"10.1111\/ijd.17085","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T07:25:16Z","timestamp":1708673116000},"page":"881-889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A systematic review of Radiesse\u00ae (calcium hydroxylapatite): evidence and recommendations for the body"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8223-2769","authenticated-orcid":false,"given":"Hassan","family":"Galadari","sequence":"first","affiliation":[{"name":"College of Medicine and Health Sciences, United Arab Emirates University  Al Ain United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8221-6694","authenticated-orcid":false,"given":"Stefania","family":"Guida","sequence":"additional","affiliation":[{"name":"School of Medicine, Vita\u2010Salute San Raffaele University  Milan Italy"},{"name":"Dermatology Clinic, IRCCS San Raffaele Scientific Institute  Milan 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neocollagenesis and skin mechanical properties after injection of diluted calcium hydroxylapatite in the neck and d\u00e9colletage: a pilot study","volume":"16","author":"Yutskovskaya YA","year":"2017","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_23_1","first-page":"534","article-title":"Prospective clinical trial evaluating the long\u2010term safety and efficacy of calcium hydroxylapatite for chest rejuvenation","volume":"20","author":"Fabi SG","year":"2021","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S407561"},{"key":"e_1_2_6_25_1","first-page":"900","article-title":"Diluted calcium hydroxylapatite for skin tightening of the upper arms and abdomen","volume":"16","author":"Lapatina NG","year":"2017","journal-title":"J Drugs 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