{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:05:33Z","timestamp":1790028333776,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melasma is a common pigmentary and photoaging disorder. Although various treatments, including 1,064\u2010nm Q\u2010switched neodymium\u2010doped yttrium aluminum garnet (QS\u2010Nd: YAG) laser toning, are available for melasma, results are often unsatisfactory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to determine the efficacy and safety of 532\u2010nm QS\u2010Nd: YAG laser (shortwave toning) in patients with melasma and facial rejuvenation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010two patients were recruited to receive either 1,064\u2010nm QS\u2010Nd: YAG laser or 532\u2010nm QS\u2010Nd: YAG laser every 2\u2009weeks for 8 sessions and a 2\u2010month follow\u2010up visit in a randomized controlled double\u2010blinded study. The primary outcome measure was the Melasma Area and Severity Index (MASI) score. Dermoscope and high\u2010frequency ultrasound (HFUS) were used to assess the improvement of melasma and photoaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>532\u2010nm QS\u2010Nd: YAG laser achieved significantly higher improvement in the MASI score (<jats:italic>P<\/jats:italic>\u2009=\u20090.000). The Dermoscopic melasma score (DMS) displayed significant change and confirmed the improvement. HFUS showed a significant decrease in the thickness of the subepidermal low\u2010echogenic band (SLEB) and increases in dermal thickness and dermal density in both groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.000 for all). The rate of very satisfied responses was significantly higher in the 532\u2010nm laser group (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). There was no significant difference in the visual analog scale pain assessment score (<jats:italic>P<\/jats:italic>\u2009=\u20090.248) and recurrence rate (<jats:italic>P<\/jats:italic>\u2009=\u20090.734) between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>532\u2010nm QS\u2010Nd: YAG laser (shortwave toning) proved to be an effective and safe treatment for melasma and rejuvenation. Shortwave toning was significantly better for pigmentation clearance, while 1,064\u2010nm laser showed better improvement in skin rejuvenation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.17091","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T11:44:59Z","timestamp":1709034299000},"page":"1242-1251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Novel 532\u2010nm Q\u2010switched Nd: YAG laser for the treatment of melasma and rejuvenation: a prospective, randomized controlled comparison with 1,064\u2010nm Q\u2010switched Nd: YAG laser"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5409-8029","authenticated-orcid":false,"given":"Wenjie","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Dermatology ZhongDa Hospital, School of Medicine, Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianya","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Dermatology ZhongDa Hospital, School of Medicine, Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuezhu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology ZhongDa Hospital, School of Medicine, Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7153-5924","authenticated-orcid":false,"given":"Yaxin","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Dermatology ZhongDa Hospital, School of Medicine, Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7546-9693","authenticated-orcid":false,"given":"Yakun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Dermatology ZhongDa Hospital, School of Medicine, Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8598-5317","authenticated-orcid":false,"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology ZhongDa Hospital, School of Medicine, Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.12.027"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.03.001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12854"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001518"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00488-w"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003635"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2012.735639"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02473.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23103"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-021-03245-w"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13629"},{"key":"e_1_2_5_13_1","first-page":"808","article-title":"A quantitative and comprehensive grading scale for rhytides, laxity, and photoaging","volume":"5","author":"Alexiades\u2010Armenakas M","year":"2006","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12033"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14927"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6836297"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmicro\/dfq068"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12250"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546631003686051"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-0963.2001.04556.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2011.00517.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22263"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-009-0729-5"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000009994"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llad266"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1708847"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14140"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/2349-5847.159389"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/2349-5847.196295"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01157.x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10025.x"},{"issue":"1","key":"e_1_2_5_32_1","first-page":"6","article-title":"Dermoscopic findings of photo\u2010ageing in Egyptian patients","volume":"11","author":"Magdy R","year":"2015","journal-title":"Egypt J Dermatol Venerol"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12913"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12294"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13219"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2004.00056.x"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13999"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12319741"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2022.0036"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20956"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2015.3921"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003602"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22582"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.17091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T06:02:55Z","timestamp":1744005775000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.17091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,27]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/ijd.17091"],"URL":"https:\/\/doi.org\/10.1111\/ijd.17091","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,27]]},"assertion":[{"value":"2023-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}