{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T04:40:17Z","timestamp":1776055217364,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sentinel lymph node biopsy is the most powerful prognostic indicator to date for cutaneous melanoma. Even though elderly patients have a lower incidence of sentinel node involvement, its results are still necessary for access to adjuvant therapies. This is highly relevant considering that the Western population shows an aging trend, and the incidence of melanoma has grown exponentially over the years, making elderly patients more likely to die from melanoma than younger ones. We performed a systematic review to investigate the prognostic significance of sentinel lymph node biopsy in elderly patients with melanoma. The systematic review was conducted following the PRISMA guidelines and registered in PROSPERO. The authors searched the Cochrane Database, EMBASE, PubMed, and WOS. Eligible studies for the systematic review were clinical trials, observational population studies, clinical or hospital\u2010based cohort studies, and case\u2013control studies. The meta\u2010analysis was conducted using the R software program applying the <jats:italic>meta<\/jats:italic> package. Six reports were identified to meet the inclusion criteria. All studies were retrospective, non\u2010randomized cohorts. The results obtained in this systematic review show a statistically significant influence of sentinel lymph node biopsy on disease\u2010specific survival (HR\u2009=\u20092.87; 95% CI: 1.73\u20134.74) but also suggest that a positive result negatively impacts disease\u2010free survival (HR\u2009=\u20093.41; 95% CI: 0.96\u201312.11). This meta\u2010analysis shows that a positive sentinel lymph node biopsy does not imply differences in overall survival but significantly influences disease\u2010specific survival and suggests an unfavorable impact on disease\u2010free survival.<\/jats:p>","DOI":"10.1111\/ijd.17092","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T15:17:21Z","timestamp":1712071041000},"page":"873-880","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic significance of sentinel lymph node biopsy in elderly with cutaneous melanoma: systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2297-2970","authenticated-orcid":false,"given":"Nieves","family":"Mart\u00ednez Campayo","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital of A Coru\u00f1a  A Coru\u00f1a Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabela","family":"Paradela de la Morena","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of A Coru\u00f1a  A Coru\u00f1a Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"P\u00e9rtega\u2010D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of Research University Hospital of A Coru\u00f1a  A Coru\u00f1a Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Tejera Vaquerizo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dermatology Institute GlobalDerms  Palma del Rio, C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of A Coru\u00f1a  A Coru\u00f1a Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.piel.2017.07.017"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010011\u20102015\u20106"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","unstructured":"Surveillance Epidemiology and End Results (SEER).Program Cancer Statistics Review 1975\u20132018.National Cancer Institute. Melanoma of the skin \u2013 Cancer Stat Fact.https:\/\/doi.org\/10.1083\/jcb.144.6.1219","DOI":"10.1083\/jcb.144.6.1219"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2010.1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.423"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.0503"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010015\u20104539\u20107"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000181092.50141.fa"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2019.0018"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7565"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-1-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-8-16"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2011.07.054"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.10.037"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2014.10.051"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.01.010"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(22)00559\u20109"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2015.12.008"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310460"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.138.10.1135"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0420-x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3464-x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.1627"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.4179"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25193"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.26736"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2004.04.015"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.16.3622"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22382"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010615)91:12<2401::AID-CNCR1274>3.0.CO;2-I"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2014.10.012"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.706"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.7567"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14019"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.17092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T06:07:36Z","timestamp":1744006056000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.17092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,2]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/ijd.17092"],"URL":"https:\/\/doi.org\/10.1111\/ijd.17092","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,2]]},"assertion":[{"value":"2023-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}