{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:26:03Z","timestamp":1789961163747,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis is a common skin disorder linked to systemic inflammation and immune dysregulation. It is believed to involve activated T cells and neutrophils. Recent research has highlighted the potential role of hematological ratios, such as neutrophil\u2010to\u2010lymphocyte ratio (NLR), platelet\u2010to\u2010lymphocyte ratio (PLR), eosinophil\u2010to\u2010lymphocyte ratio (ELR), eosinophil\u2010to\u2010neutrophil ratio (ENR), and eosinophil\u2010to\u2010monocyte ratio (EMR), as markers for inflammatory skin diseases, including psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to investigate hematological ratios between children and adults, patients and controls, and patients with moderate\u2010to\u2010severe and mild psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This national retrospective cohort study included over 16,000 psoriasis patients in Israel. Patients with comorbidities influencing blood counts were excluded. Ratios were calculated from blood counts taken within 30\u2009days of diagnosis. Multivariable logistic regression, including age, gender, ethnicity, smoking status, and socioeconomic status, was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Findings revealed age\u2010specific variations in blood counts, hematological ratios, and differences between mild and moderate\u2013severe patients and patients versus controls. Moderate\u2013severe psoriasis patients had elevated neutrophil and eosinophil counts (4.57 vs. 4.25, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, and 0.24 vs. 0.22, <jats:italic>P<\/jats:italic>\u2009=\u20090.047, respectively), as well as increased NLR (2.46 vs. 2.29, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Multivariable logistic regression analysis confirmed the significance of neutrophil and platelet counts as well as NLR and PLR in predicting psoriasis severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>This was a retrospective study without subjective data on disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study highlights hematologic ratios' diagnostic and prognostic potential in psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.17133","type":"journal-article","created":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T05:19:40Z","timestamp":1709961580000},"page":"1369-1374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association of hematological ratios with psoriasis: a nationwide retrospective cohort study"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5284-9805","authenticated-orcid":false,"given":"Sarah","family":"Weissmann","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer Sheva Israel"},{"name":"Clinical Research Unit Soroka University Medical Center  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit S.","family":"Babyev","sequence":"additional","affiliation":[{"name":"Clinical Research Unit Soroka University Medical Center  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Gordon","sequence":"additional","affiliation":[{"name":"Clinical Research Unit Soroka University Medical Center  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6259-405X","authenticated-orcid":false,"given":"Inbal","family":"Golan\u2010Tripto","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer Sheva Israel"},{"name":"Pediatric Pulmonary Unit Soroka University Medical Center  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6646-9061","authenticated-orcid":false,"given":"Amir","family":"Horev","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer Sheva Israel"},{"name":"Pediatric Dermatology Service Soroka University Medical Center  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,8]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"StatPearls","author":"Nair 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of neutrophil\u2010to\u2010lymphocyte ratio and platelet\u2010to\u2010lymphocyte ratio in Turkish patients with chronic plaque psoriasis","volume":"26","author":"Polat M","year":"2017","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.17133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T05:45:25Z","timestamp":1744004725000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.17133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,8]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/ijd.17133"],"URL":"https:\/\/doi.org\/10.1111\/ijd.17133","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,8]]},"assertion":[{"value":"2024-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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