{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:37:42Z","timestamp":1790231862856,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T00:00:00Z","timestamp":1712448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>IL\u201023 inhibitors were recently approved for the treatment of skin psoriasis and psoriatic arthritis (PsA). Risankizumab, a humanized monoclonal antibody that specifically binds the p19 subunit of IL\u201023, has proven effective on PsA in two randomized controlled trials. To date, only a few real\u2010world data are available on this topic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our study aimed to prospectively evaluate the effectiveness of risankizumab in patients with PsA in a real\u2010world setting. For this purpose, both rheumatologic and dermatologic assessments were performed at baseline and after 28\u201340\u2009weeks of continuous risankizumab administration. Moreover, joint and entheses ultrasound assessment was performed at the mentioned time points.<\/jats:p><jats:p>The rheumatologic assessment was carried out by means of the following scores: (i) clinical Disease Activity Index for Psoriatic Arthritis (cDAPSA); (ii) Leeds Enthesitis Index (LEI); (iii) Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and (iii) Bath Ankylosing Spondylitis Functional Index (BASFI). The degree of skin involvement was measured by both the Psoriasis Area and Severity Index (PASI) and Physician Global Assessment (PGA). Quality of life was assessed by the Health Assessment Questionnaire (HAQ) and Dermatology Life Quality Index (DLQI). Ultrasound assessment of joints and entheses was performed on the basis of the EULAR\u2010OMERACT score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After treatment, cDAPSA decreased from a mean value of 12.9\u2009\u00b1\u20097.6 to 7.0\u2009\u00b1\u20096.1 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and the median PD score significantly decreased from baseline (3; range 1\u20138) to TP1 (1; range 0\u20137) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). PASI score also decreased from 8.4\u2009\u00b1\u20094.9 to 0.3\u2009\u00b1\u20090.5 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and PGA from 3.1\u2009\u00b1\u20091.0 to 0.4\u2009\u00b1\u20090.5 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We can conclude that risankizumab led to substantial improvement in both skin and joint involvement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.17156","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T03:33:47Z","timestamp":1712547227000},"page":"1383-1391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effectiveness of risankizumab for the treatment of psoriatic arthritis: a multicenter, real\u2010world study"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3938-0939","authenticated-orcid":false,"given":"Dario","family":"Graceffa","sequence":"first","affiliation":[{"name":"Department of Clinical Dermatology San Gallicano Dermatological Institute, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Zangrilli","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Rome Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Caldarola","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche e Chirurgiche UOC di Dermatologia, Fondazione Policlinico Universitario A. 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