{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:59:34Z","timestamp":1780880374358,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Demodex density is known to increase in various immunosuppressive conditions. The relationship between biologic therapy and Demodex density remains unknown. We aimed to investigate whether the density of Demodex mites is higher in psoriasis patients treated with biologic agents compared to treatment\u2010naive or topically treated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was conducted, comparing psoriasis patients receiving biologic therapy (<jats:italic>n<\/jats:italic>\u2009=\u200934) with controls (<jats:italic>n<\/jats:italic>\u2009=\u200933). Demodex density was assessed using the standardized skin surface biopsy technique (<jats:styled-content style=\"fixed-case\">SSSB<\/jats:styled-content>). Statistical analysis was performed to compare the densities and prevalence of demodicosis between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Demodex density was significantly higher in the biologic therapy group compared to the control group on the right cheek (7.29 vs. 0.12\/cm<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>\u2009=\u20090.001), left cheek (8.15 vs. 0.24\/cm<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>\u2009=\u20090.002), and whole face (average of all four regions: 5.50 vs. 0.80\/cm<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>\u2009=\u20090.001). The prevalence of demodicosis was significantly higher in the biologic therapy group on the forehead (35.3% vs. 12.1%; <jats:italic>P<\/jats:italic>\u2009=\u20090.043), right cheek (41.2% vs. 0%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and left cheek (44.1% vs. 0%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The frequency of cases with demodicosis in at least one localization was higher in the biological therapy group compared to the control group (61.8% vs. 15.2%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Psoriasis patients receiving biologic therapy had a higher Demodex density and prevalence of demodicosis compared to controls. Biologics may lead to an increase in Demodex density by blocking specific cytokines, such as interleukin\u201017 and tumor necrosis factor\u2010\u03b1, which play a role in immunity against Demodex. Further research is needed to explore the impact of different biological agents on Demodex density.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.17161","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T04:23:30Z","timestamp":1713846210000},"page":"1193-1199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Biologic therapy increases Demodex density in psoriasis patients"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5207-9633","authenticated-orcid":false,"given":"Hasan","family":"Aksoy","sequence":"first","affiliation":[{"name":"Department of Dermatology Istanbul Medeniyet University Prof. Dr. Suleyman Yalcin City Hospital  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00fcmeyye","family":"Alt\u0131nta\u015f Kak\u015fi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Istanbul Medeniyet University Prof. Dr. Suleyman Yalcin City Hospital  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2066-5662","authenticated-orcid":false,"given":"\u00d6yk\u00fc","family":"G\u00f6n\u00fcll\u00fc","sequence":"additional","affiliation":[{"name":"Department of Dermatology Istanbul Medeniyet University Prof. Dr. Suleyman Yalcin City Hospital  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4347-3134","authenticated-orcid":false,"given":"Melek","family":"Aslan Kay\u0131ran","sequence":"additional","affiliation":[{"name":"Department of Dermatology Istanbul Medeniyet University Prof. Dr. Suleyman Yalcin City Hospital  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vefa A.","family":"Erdemir","sequence":"additional","affiliation":[{"name":"Department of Dermatology Istanbul Medeniyet University Prof. Dr. Suleyman Yalcin City Hospital  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-33224-1_176"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15910"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb00261.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12850"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2005.00103.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.125625"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338693"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03336.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2022.120879"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04310.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12673"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56030107"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000323001"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13462"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(01)00194-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14437"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2019.1644349"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2011.03465.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2010.08.009"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2011.26.9.1231"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2001.00331.x"},{"key":"e_1_2_7_24_1","first-page":"1047","article-title":"D\u00e9modex et inflammation p\u00e9rifolliculaire chez l'homme: revue et observation de 69 biopsies [Demodex and perifollicular inflammation in man: review and report of 69 biopsies]","volume":"113","author":"Forton F","year":"1986","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171849"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.17161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T06:01:31Z","timestamp":1744005691000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.17161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,22]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/ijd.17161"],"URL":"https:\/\/doi.org\/10.1111\/ijd.17161","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,22]]},"assertion":[{"value":"2023-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}