{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:17:39Z","timestamp":1747185459615,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["1K23AR079586"],"award-info":[{"award-number":["1K23AR079586"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54DK083909"],"award-info":[{"award-number":["U54DK083909"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Erythropoietic protoporphyria (EPP) causes painful light sensitivity, limiting quality of life. Our objective was to develop and validate a wearable light exposure device and correlate measurements with light sensitivity in EPP to predict and prevent symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A wearable light dosimeter was developed to capture light doses of UVA, blue, and red wavelengths. A prospective observational pilot study was performed in which five EPP patients wore two light dosimeters for 3\u2009weeks, one as a watch, and one as a shirt clip.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Standard deviation (SD) increases from the mean in the daily blue light dose increased the odds ratio (OR) for symptom risk more than the self\u2010reported outdoor time (OR 2.76 vs. 2.38) or other wavelengths, and a one SD increase from the mean in the daily blue light wristband device dose increased the OR for symptom risk more than the daily blue light shirt clip (OR 2.45 vs. 1.62). The area under the receiver operator curve for the blue light wristband dose was 0.78, suggesting 78% predictive accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data demonstrate that wearable blue light dosimetry worn as a wristband is a promising method for measuring light exposure and predicting and preventing symptoms in EPP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.17166","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T08:49:58Z","timestamp":1712825398000},"page":"1584-1591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Observational pilot study of multi\u2010wavelength wearable light dosimetry for erythropoietic protoporphyria"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2979-9664","authenticated-orcid":false,"given":"Amy K.","family":"Dickey","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Massachusetts General Hospital  Boston MA USA"},{"name":"Harvard Medical School  Boston MA USA"},{"name":"Healthcare Transformation Lab Massachusetts General Hospital  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Berkovich","sequence":"additional","affiliation":[{"name":"Wearifi, Inc.  Evanston IL USA"},{"name":"Querrey Simpson Institute for Bioelectronics, Northwestern University  Evanston IL USA"},{"name":"Northwestern University Department of Materials Science and Engineering  Evanston IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca K.","family":"Leaf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Massachusetts General Hospital  Boston MA USA"},{"name":"Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2016-6556","authenticated-orcid":false,"given":"Paul Y.","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Massachusetts General Hospital  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisela","family":"Lopez\u2010Galmiche","sequence":"additional","affiliation":[{"name":"Neurolux Inc.  Evanston IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Rebeiz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Massachusetts General Hospital  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"Wheeden","sequence":"additional","affiliation":[{"name":"United Porphyrias Association  Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Kochevar","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston MA USA"},{"name":"Department of Dermatology Massachusetts General Hospital  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Savage","sequence":"additional","affiliation":[{"name":"Disc Medicine  Watertown MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Zhao","sequence":"additional","affiliation":[{"name":"Analytica Now LLC  Brookline MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Campisi","sequence":"additional","affiliation":[{"name":"Wearifi, Inc.  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