{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:33:04Z","timestamp":1782973984894,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Tirbanibulin 1% ointment is approved for the field treatment of Olsen grade I actinic keratoses (AKs) of the face and scalp.<\/jats:p><\/jats:sec>Methods<\/jats:title>We performed a multicenter retrospective study involving 15 dermatologic units in Italy to investigate the efficacy and tolerability of tirbanibulin in a real\u2010life setting. 250 patients were enrolled. Tirbanibulin, 1% ointment, was applied daily for five consecutive days. The efficacy of treatment was measured with modifications of the Actinic Keratosis Area and Severity Index (AKASI). A satisfactory response was defined by complete (100% reduction in the number of lesions) or partial clearance (75\u201399%) of treated AKs.<\/jats:p><\/jats:sec>Results<\/jats:title>Overall, the AKASI score was significantly reduced in the studied population (mean, from 4.1\u2009\u00b1\u20092.7 to 1.4\u2009\u00b1\u20091.5; P<\/jats:italic>\u2009<\u20090.001). A satisfactory response was observed in 222 (88.8%) cases. The proportion of satisfactory responses was higher when follow\u2010up was performed after 8\u2009weeks (34\/35, 97.1%). The reduction in AKASI was significant in patients with Olsen grade II or III lesions (from 5.3\u2009\u00b1\u20092.8 to 1.6\u2009\u00b1\u20091.6; P<\/jats:italic>\u2009<\u20090.001). A satisfactory response was observed in 91\/104 (87.5%) cases. AKASI reduction was also significant in patients with trunk or limb AKs (from 7.0\u2009\u00b1\u20091.3 to 2.0\u2009\u00b1\u20091.6; P<\/jats:italic>\u2009=\u20090.018) since a satisfactory response was observed in 7\/8 (87.5%) cases. Tirbanibulin was well tolerated; all adverse events (AEs) included transient local reactions at the site of treatment. Overall, 231 patients had at least one AE. Only 7 (2.8%) grade 4 AEs were recorded.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our retrospective study confirmed that tirbanibulin 1% ointment is effective and well tolerated in a real\u2010life setting and is also promising for Olsen grade II and grade III AKs and AKs localized on difficult\u2010to\u2010treat areas.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.17168","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T04:50:26Z","timestamp":1712897426000},"page":"1566-1574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Efficacy and tolerability of tirbanibulin 1% ointment in the treatment of cancerization field: a real\u2010life Italian multicenter observational study of 250 patients"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8534-6497","authenticated-orcid":false,"given":"Gianluca","family":"Nazzaro","sequence":"first","affiliation":[{"name":"Dermatology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8231-2205","authenticated-orcid":false,"given":"Andrea","family":"Carugno","sequence":"additional","affiliation":[{"name":"Dermatology Unit ASST Papa Giovanni XXIII Bergamo Italy"},{"name":"University of Milan\u2010Bicocca Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bortoluzzi","sequence":"additional","affiliation":[{"name":"Dermatology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8301-9206","authenticated-orcid":false,"given":"Emanuele","family":"Trovato","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical, Surgical and Neurological Sciences University of Siena Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Caccavale","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine University of Campania Luigi Vanvitelli Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine University of Campania Luigi Vanvitelli Naples 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Valenti","sequence":"additional","affiliation":[{"name":"Dermatology Unit IRCCS Humanitas Research Hospital Rozzano Italy"},{"name":"Department of Biomedical Sciences Humanitas University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Toni","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Infectious Diseases, Department of Medical Sciences University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0464-3356","authenticated-orcid":false,"given":"Serena","family":"Giacalone","sequence":"additional","affiliation":[{"name":"Institute of Dermatology, ASST Valle Olona, Ospedale Sant'Antonio Abate Gallarate Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Zavattaro","sequence":"additional","affiliation":[{"name":"Department 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