{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:52:35Z","timestamp":1787165555446,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We aimed to investigate the prevalence of skin disease among patients with systemic lupus erythematosus (SLE) and determine whether LE skin disease had clinical or serologic correlates with SLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed records of 335 patients with SLE (seen at Mayo Clinic, Rochester, Minnesota, USA) and abstracted skin manifestations, fulfilled mucocutaneous SLE criteria, and clinical and serologic parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 231 patients with skin manifestations, 57 (24.7%) had LE\u2010specific conditions, 102 (44.2%) had LE\u2010nonspecific conditions, and 72 (31.2%) had both. LE skin disease was associated with photosensitivity, anti\u2010Smith antibodies, and anti\u2010U1RNP antibodies (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Patients without LE skin disease more commonly had elevated C\u2010reactive protein levels (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01). Patients meeting 2\u20134 mucocutaneous American College of Rheumatology criteria less commonly had cytopenia (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004) or anti\u2212double\u2010stranded DNA antibodies (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004). No significant associations were observed for systemic involvement (renal, hematologic, neurologic, and arthritis) when comparing patients with or without LE skin involvement. LE skin involvement was not significantly associated with internal SLE disease flare, number of medications, or overall survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LE skin disease commonly occurs in patients with SLE. The presence of LE skin disease had no mitigating impact on the severity of SLE sequelae, disease flares, number of medications, or overall survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.17178","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T08:05:33Z","timestamp":1715328333000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Systemic correlates of cutaneous manifestations of lupus erythematosus"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4326-2871","authenticated-orcid":false,"given":"Peter M.","family":"Heil","sequence":"first","affiliation":[{"name":"Department of Dermatology Medical University of Vienna  Vienna Austria"},{"name":"Visiting Research Fellow, Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Pittelkow","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Scottsdale AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Weaver","sequence":"additional","affiliation":[{"name":"Division of Clinical Trials and Biostatistics Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill M.","family":"Killian","sequence":"additional","affiliation":[{"name":"Division of Clinical Trials and Biostatistics Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8060-4311","authenticated-orcid":false,"given":"Olayemi","family":"Sokumbi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Jacksonville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Wetter","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(81)80261-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.8.1033"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34473"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40930"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203319856091"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310367656"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.53189"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/S0049-0172(03)00133-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.d01-1004.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1987.tb00108.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.37.2.121"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.6.717"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1996.tb03021.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-195412000-00001"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1964.03070150014003"},{"key":"e_1_2_6_18_1","first-page":"1","article-title":"Systemic lupus erythematosus. 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