{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:04:19Z","timestamp":1787619859415,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T00:00:00Z","timestamp":1715990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Acne vulgaris is a chronic inflammatory dermatosis.\n                      <jats:italic>Cutibacterium acnes<\/jats:italic>\n                      plays a crucial role in the acne pathophysiology. Recent works present evidence of\n                      <jats:italic>C.\u00a0acnes<\/jats:italic>\n                      growing as a biofilm in cutaneous follicles. This development is currently considered one of the leading causes of\n                      <jats:italic>C. acnes in vivo<\/jats:italic>\n                      persistence and resistance to antimicrobials used to treat acne.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Our objective was to evaluate the effects of various active compounds (clindamycin, erythromycin, doxycycline, and myrtle extract) on eight distinct, well\u2010characterized strains of\n                      <jats:italic>C. acnes<\/jats:italic>\n                      following their growth in biofilm mode.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\/Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Cutibacterium acnes<\/jats:italic>\n                      isolates from phylotypes IA\n                      <jats:sub>1<\/jats:sub>\n                      and IA\n                      <jats:sub>2<\/jats:sub>\n                      produce more biofilm than other phylotypes. No antibiotic effect was observed either during the curative test or preventive test. Myrtle extract at 0.01% (w\/v) showed significant efficacy on the biofilm for\n                      <jats:italic>C. acnes<\/jats:italic>\n                      strains (curative assays). Furthermore, it appear that myrtle extract and doxycycline together reduce the overall biomass of the biofilm. A significant dose\u2010dependent effect was observed during the preventive test, greater than the one observed under curative conditions, with an important loss of activity of the myrtle extract observed from 0.001% (w\/v) concentration onwards. Transmission electron microscopy showed that bacteria treated with\u00a0myrtle extract grew biofilms much less frequently than untreated bacteria. Additionally, when the quantity of myrtle extract grew, the overall number of bacteria dropped, indicating an additional antibacterial action.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These findings support the hypothesis that the different\n                      <jats:italic>C. acnes<\/jats:italic>\n                      phylotypes have various aptitudes in forming biofilms. They also suggest that myrtle extract is a promising alternative as an anti\u2010biofilm and antibacterial agent in fighting diseases caused by planktonic and biofilm\n                      <jats:italic>C. acnes<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.17194","type":"journal-article","created":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T03:14:50Z","timestamp":1716002090000},"page":"1541-1550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Biofilm of\n                    <i>Cutibacterium acnes<\/i>\n                    : a target of different active substances"],"prefix":"10.1111","volume":"63","author":[{"given":"Louise","family":"Ruffier d'Epenoux","sequence":"first","affiliation":[{"name":"Service de Bact\u00e9riologie et des Contr\u00f4les Microbiologiques, CHU  Nantes France"},{"name":"Universit\u00e9 de Nantes, 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