{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T14:39:50Z","timestamp":1782052790300,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite its rarity, porphyria cutanea tarda (PCT) is globally recognized as the most common form of cutaneous porphyria. This study aims to review the underlying associations and treatment of PCT in Scotland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed data on 27 patients diagnosed with PCT between 1987 and 2022 at the Scottish Cutaneous Porphyria Service.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Males slightly predominated (66.7%). The mean\u2009\u00b1\u2009standard deviation (SD) age at diagnosis was 55.6\u2009\u00b1\u200912.5\u2009years. Common associated factors were heavy alcohol intake (88.5%), genetic hemochromatosis (72%), smoking (45.5%), and hepatitis C virus infection (16%). Most had multiple associated factors (70.4%). Patients with genetic hemochromatosis with the C282Y genotype exhibited higher median transferrin saturation (69.5 vs. 35,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004) and ferritin levels (observed in males only) (1175 vs. 339;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.014) than those with the H636D genotype. Most (52%) received combination therapy of venesection and antimalarials, followed by venesection monotherapy (32%) and antimalarial monotherapy (16%). Overall, 95.2% achieved biochemical improvement. Median time to improvement was 7, 5, and 9\u2009months with venesection, antimalarial, and combined treatments, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.173). Biochemical remission was achieved in 50% of patients. Remission occurred in 2\/4 of patients with antimalarial monotherapy (median time 19\u2009months) and 9\/13 patients with combined treatment (median time 26\u2009months). Biochemical relapse was found in three patients, all of whom received combination therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Excess alcohol intake and genetic hemochromatosis were the most common underlying associations with PCT in our Scottish cohort. Treatment for PCT should be individualized, and long\u2010term follow\u2010up is needed to monitor for disease relapse.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.17205","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T08:04:58Z","timestamp":1713773098000},"page":"1707-1712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Porphyria cutanea tarda in Scotland: underlying associations and treatment approaches"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3161-5206","authenticated-orcid":false,"given":"Chayada","family":"Chaiyabutr","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"},{"name":"Scottish Photobiology Service, Photobiology Unit University of Dundee &amp; NHS Tayside, Ninewells Hospital &amp; Medical School  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4732-071X","authenticated-orcid":false,"given":"Robert","family":"Dawe","sequence":"additional","affiliation":[{"name":"Scottish Photobiology Service, Photobiology Unit University of Dundee &amp; NHS Tayside, Ninewells Hospital &amp; Medical School  Dundee UK"},{"name":"Scottish Cutaneous Porphyria Service, Photobiology Unit University of Dundee &amp; NHS Tayside, Ninewells Hospital &amp; Medical School  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally H.","family":"Ibbotson","sequence":"additional","affiliation":[{"name":"Scottish Photobiology Service, Photobiology Unit University of Dundee &amp; NHS Tayside, Ninewells Hospital &amp; Medical School  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Clarke","sequence":"additional","affiliation":[{"name":"Scottish Photobiology Service, Photobiology Unit University of Dundee &amp; NHS Tayside, Ninewells Hospital &amp; Medical School  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7808-3278","authenticated-orcid":false,"given":"Victoria A.","family":"McGuire","sequence":"additional","affiliation":[{"name":"Scottish Photobiology Service, Photobiology Unit University of Dundee &amp; NHS Tayside, Ninewells Hospital &amp; Medical School  Dundee UK"},{"name":"Scottish Cutaneous Porphyria Service, Photobiology Unit University of Dundee &amp; NHS Tayside, Ninewells Hospital &amp; Medical School  Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2009.00394.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2019.01.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16741"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14398"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013746828074"},{"issue":"1","key":"e_1_2_7_7_1","first-page":"1231A","article-title":"Relapse of porphyria cutanea tarda after achieving remission with phlebotomy or low dose hydroxychloroquine","volume":"62","author":"Singal AK","year":"2015","journal-title":"Hepatology"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.08.038"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1983.tb01062.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1980.01640290053010"},{"key":"e_1_2_7_11_1","first-page":"S1","article-title":"Diagnosis of porphyria\u2014recommended methods for peripheral laboratories","volume":"13","author":"Blake D","year":"1992","journal-title":"Clin Biochem Rev"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(84)90192-X"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/109065701753145583"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880010600751918"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.10101.1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2001.00825.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0260"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04205.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009745"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg169"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.17205","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijd.17205","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.17205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:23:19Z","timestamp":1773015799000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.17205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,22]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/ijd.17205"],"URL":"https:\/\/doi.org\/10.1111\/ijd.17205","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,22]]},"assertion":[{"value":"2024-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}