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Although biologic agents have offered transformative therapeutic advantages to those unresponsive to traditional treatments, data from recent literature indicate significant undertreatment of certain populations, highlighting potential barriers to access. This review aims to comprehensively elucidate barriers to biological therapy, addressing a recognized gap in the current literature. A search was conducted using MEDLINE, Embase, and Web of Science to investigate the obstacles and disparities that prevent access to biologic treatments in biologic\u2010na\u00efve psoriatic patients. Emergent themes were then systematically categorized into five primary domains: patient\u2010level, prescriber\u2010level, medicine\u2010level, organizational\u2010, and external environment\u2010level factors. Our results demonstrate pronounced barriers and disparities encompassing increased age, race, socioeconomic status, rural location, cost and insurance, and insufficient knowledge that may hinder access to biologic treatments among psoriatic patients. Further research on how these barriers can be effectively addressed is needed to optimize treatment outcomes.<\/jats:p>","DOI":"10.1111\/ijd.17236","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T04:45:19Z","timestamp":1717735519000},"page":"1293-1301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Disparities and barriers to the access of biologics in moderate\u2010to\u2010severe adult psoriasis"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4032-5286","authenticated-orcid":false,"given":"Vincent","family":"Wan","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Habibi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of British Columbia  Vancouver BC 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