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This study aims to characterize the clinical symptoms, presentations, and treatments of nSCC in patients with darker skin types. A systematic review of PubMed and Embase was performed\u00a0in May 2023 for all peer\u2010reviewed, English\u2010language nSCC studies involving individuals with Fitzpatrick types IV\u2013VI. Most tumors were located on the fingernails (84%), with the right third finger being the most frequently affected (31%). The nail bed (67%) exhibited a higher prevalence than the lateral\/proximal nail folds (33%). The duration of symptoms before diagnosis ranged from 1\u2009month to 7\u2009years. nSCC was most commonly treated with Mohs surgery (38%), followed by amputation (35%). Our study was limited to case reports because of a lack of large nSCC studies that provide information on race or images of each patient. These tumors are generally slow\u2010growing yet often misdiagnosed, leading to delays in presentation and diagnosis. Increased awareness about nSCC in phototype IV\u2013VI individuals will reduce misdiagnoses, unnecessary treatment, and recurrences.<\/jats:p>","DOI":"10.1111\/ijd.17237","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T04:23:37Z","timestamp":1715574217000},"page":"1302-1307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Squamous cell carcinoma of the nail in patients with Fitzpatrick phototypes <scp>IV\u2013VI<\/scp>: a systematic review"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8974-9151","authenticated-orcid":false,"given":"Michelle J.","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Dermatology State University of New York Downstate Medical Center  Brooklyn NY USA"},{"name":"Department of Dermatology Veterans Affairs Medical Center  Brooklyn New York 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