{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:50:19Z","timestamp":1789631419522,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Key point<\/jats:title><jats:p>The 1064\u2010nm picosecond laser with holographic optics demonstrated significant efficacy in treating atrophic acne scars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Picosecond lasers with fractionated optics have enabled the development of\u00a0a breakthrough skin rejuvenation method. The authors compared the fractionated, non\u2010ablative neodymium\u2010doped yttrium aluminum garnet 1064\u2010nm picosecond laser with holographic optics and the fractional CO<jats:sub>2<\/jats:sub> laser in treating atrophic acne scars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One side of each patient's face was randomly allocated and treated with three sessions of the 1064\u2010nm picosecond laser with holographic optics at 2\u2010month intervals. In contrast, the other side was treated with the fractional CO<jats:sub>2<\/jats:sub> laser. Participants were followed up 3 months after the final session. The primary outcome included the physicians' evaluation using the ECCA grading scale and a four\u2010point scale to assess improvement. The patients' assessment of progress, their overall satisfaction and preferences, and the side effects were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant difference was observed between the two lasers in terms of the mean ECCA scores after treatments (<jats:italic>P<\/jats:italic>\u2009=\u20090.209). The physicians' improvement assessment was more significant for the fractional CO<jats:sub>2<\/jats:sub> laser (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). The patients' evaluation of improvement and subjective satisfaction were consistent with physicians' four\u2010point scale results. The picosecond laser side had fewer adverse effects (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The fractionated, non\u2010ablative Nd: YAG 1064\u2010nm picosecond laser with holographic optics and the fractional CO<jats:sub>2<\/jats:sub> laser were effective and safe in treating atrophic acne scars. Significantly better clinical outcomes were observed with the fractional CO<jats:sub>2<\/jats:sub> laser, whereas fewer adverse effects were noted with the 1064\u2010nm picosecond laser with holographic optics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.17296","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T02:49:56Z","timestamp":1719283796000},"page":"85-91","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of the fractionated Nd: YAG 1064\u2010nm picosecond laser with holographic optics and the fractional CO<sub>2<\/sub> laser in atrophic acne scar treatment: a prospective, randomized, split\u2010face study"],"prefix":"10.1111","volume":"64","author":[{"given":"Yucheng","family":"Yuan","sequence":"first","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhen","family":"He","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Fang","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7720-4982","authenticated-orcid":false,"given":"Qiuju","family":"Wu","sequence":"additional","affiliation":[{"name":"Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Nanjing Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00628-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00451-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2322-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1606096"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.08.051"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10870.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.3045"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001669"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2018.1481514"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22734"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23404"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2007.00403.x-i1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12103"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000096912"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.07.047"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22443"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13941"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23014"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23151"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-019-02906-1"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002572"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22540"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201100083"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22752"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23177"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23389"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.17296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T02:59:41Z","timestamp":1735613981000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.17296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,24]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/ijd.17296"],"URL":"https:\/\/doi.org\/10.1111\/ijd.17296","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,24]]},"assertion":[{"value":"2023-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}