{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:18:28Z","timestamp":1773019108356,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is a limited number of studies assessing the alterations in nerve function impairment (NFI) in leprosy over an extended period of time. To the best of our knowledge, no published study has evaluated neurological state longitudinally during treatment utilizing a combination of clinical, functional (activity limitation), electrophysiological, and patient\u2010reported quality of life (QOL) outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, observational study included leprosy patients of all spectra. Over 1 year of treatment, cutaneous and neurological examinations were done in addition to a nerve conduction study (NCS) and sympathetic skin response (SSR) assessment. QOL and activity limitation assessments using the World Health Organization Quality of Life brief version (WHOQOL\u2013BREF) and Screening of Activity Limitation and Safety Awareness scale (SALSA), respectively, were also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Out of 63 leprosy patients, loss of sensation was noted in 43 (68.2%) at baseline. At the completion of treatment, proportionate change revealed no change in 18 (28.5%), restored function in 9 (14.2%), improved status in 34 (53.9%), and deteriorated NFI in only 2 (3.1%) cases. The association between NCS\u2010SSR abnormalities was significant for a longer duration of disease at presentation (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.04), in multibacillary cases [OR 9.12 (95% CI, 1.22\u201367.93)], in those in reaction [OR 3.56 (95% CI, 0.62\u201320.36)] and in those aged over 40 [OR 1.93 (95% CI, 0.28\u201313.41)]. There was an improvement in WHOQOL\u2010BREF and SALSA scores at release from treatment (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.005 and\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The majority of leprosy patients on treatment show improvement in NFI at the completion of therapy. However, change is influenced by critical factors such as bacillary load, disease duration, age, and the presence of reaction(s).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.17323","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T03:45:00Z","timestamp":1718336700000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nerve function impairment and quality of life in patients with leprosy: a prospective, observational study"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9495-7502","authenticated-orcid":false,"given":"Apoorva","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0464-2989","authenticated-orcid":false,"given":"Tarun","family":"Narang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aastha","family":"Takkar","sequence":"additional","affiliation":[{"name":"Department of Neurology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bijaya Kumar","family":"Padhi","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and School of Public Health Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil","family":"Dogra","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"S146","article-title":"Peripheral neuropathy in leprosy and its consequences","volume":"71","author":"Van Brakel WH","year":"2000","journal-title":"Lepr Rev"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.47276\/lr.76.1.14"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000498"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.47276\/lr.80.1.34"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.47276\/lr.77.4.371"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(87)80189-2"},{"issue":"3","key":"e_1_2_7_8_1","first-page":"305","article-title":"Reliability of Semmes Weinstein monofilament and ballpoint sensory testing, and voluntary muscle testing in Bangladesh","volume":"70","author":"Anderson AM","year":"1999","journal-title":"Lepr Rev"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.47276\/lr.78.4.416"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e3181cb426d"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02216-9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.865485"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005111"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e31824d969c"},{"key":"e_1_2_7_15_1","first-page":"1273","article-title":"DNTc neurophysiological, radiological and neuropathological study of Hansen's disease in hamidia hospital Bhopal","volume":"4","author":"Dubey TN","year":"2017","journal-title":"Int J Contemp Med Res"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inhe.2011.09.006"},{"issue":"1","key":"e_1_2_7_17_1","first-page":"29","article-title":"Development and evolution of nerve damage in individuals with leprosy during medical treatment, at completion of MDT and after release from treatment","volume":"89","author":"Lopes LBM","year":"2017","journal-title":"Indian J Lepr"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3823\/2573"},{"issue":"3","key":"e_1_2_7_19_1","first-page":"273","article-title":"The ALERT MDT Field Evaluation Study (AMFES): a descriptive study of leprosy in Ethiopia. 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