{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:56Z","timestamp":1787014376064,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Abrocitinib, a selective JAK 1 inhibitor, was recently approved in Europe. Despite its approval, real\u2010world data on its efficacy and safety in treating moderate\u2010to\u2010severe atopic dermatitis (AD) remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate the short\u2010term effectiveness and safety of abrocitinib in a real\u2010life setting for patients with moderate\u2010to\u2010severe AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective multicenter study involving adult patients with moderate\u2010to\u2010severe AD who started abrocitinib treatment between May 1, 2023, and September 30, 2023, in 15 Spanish hospitals. Treatment doses were 100 or 200\u2009mg daily, based on clinical assessment. Data collection included patient demographics, AD history, comorbidities, previous treatments, and disease severity indicators such as SCORing atopic dermatitis (SCORAD), Eczema Area and Severity Index (EASI), body surface area, and Peak Pruritus NRS scores at baseline, 4, 12, and 24\u2009weeks. Quality of life was measured using the Dermatology Life Quality Index (DLQI), and safety was assessed by monitoring adverse reactions and various biochemical parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cohort comprised 76 patients with an average age of 33.93\u2009years; 57.89% were male. Before abrocitinib, 36.84% were na\u00efve to advanced therapies. The baseline mean scores were SCORAD 47.04, EASI 21.79, and DLQI 15.01. At Week 24, there were significant improvements: EASI was reduced to 2.81, and 70.58% of the patients achieved EASI 75. However, 18.42% discontinued treatment mainly due to inefficacy or adverse effects. The safety profile was favorable, with 22.37% reporting mild adverse events (AEs) and one serious case of cutaneous lymphoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This first Spanish series assessing abrocitinib in real\u2010world conditions reveals a significant improvement in AD symptoms and quality of life in a range of severity and prior treatment failures. Abrocitinib was well\u2010tolerated, with few serious AEs, highlighting its potential as an effective treatment option for AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijd.17344","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T23:53:26Z","timestamp":1719014006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Treatment of atopic dermatitis with abrocitinib in real practice in Spain: efficacy and safety results from a 24\u2010week multicenter study"],"prefix":"10.1111","volume":"63","author":[{"given":"Jose Carlos","family":"Armario\u2010Hita","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital of Puerto Real, University of C\u00e1diz  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6843-5877","authenticated-orcid":false,"given":"Jose Juan","family":"Pereyra\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Virgen del Roc\u00edo  Sevilla Spain"},{"name":"Department of Medicine, School of Medicine University of Sevilla  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Gonz\u00e1lez\u2010Quesada","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Dr. Negrin  Gran Canarias Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Herranz","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital La Paz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Suarez","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Galan\u2010Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Reina Sofia  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Rodr\u00edguez\u2010Serna","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Ortiz de Frutos","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4266-0771","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Carrascosa","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Germans Trias i Pujol  Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Serra\u2010Baldrich","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital San Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Ara\u2010Martin","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Lozano Blesa  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignasi","family":"Figueras\u2010Nart","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Bellvitge  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Francisco","family":"Silvestre","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Alicante  Alicante 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